Evidence map›Paper›PMID 28768972›Full record

ArticleInternal medicine (Tokyo, Japan)2017

Extranodal NK/T-cell Lymphoma, Nasal Type Accompanied by PR3-ANCA-associated Glomerulonephritis.

Yuta Tamoto, Ryo Ishida, Kazuya Shiogama, Hiroshi Kado, Michitsugu Kamezaki, Yoshiaki Chinen, Yosuke Matsumoto, Tetsuro Kusaba, Eiichi Konishi, Yutaka Tsutsumi and 1 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yuta TamotoDivision of Nephrology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Ryo IshidaDivision of Nephrology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Kazuya ShiogamaDepartment of Pathology, Fujita Health University School of Medicine, Japan.
Hiroshi KadoDivision of Nephrology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Michitsugu KamezakiDivision of Nephrology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Yoshiaki ChinenDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Yosuke MatsumotoDepartments of Hematology and Laboratory Medicine, Aiseikai Yamashina Hospital, Japan.
Tetsuro KusabaDivision of Nephrology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Eiichi KonishiDepartment of Surgical Pathology, Kyoto Prefectural University of Medicine, Japan.
Yutaka TsutsumiDepartment of Pathology, Fujita Health University School of Medicine, Japan.
Keiichi TamagakiDivision of Nephrology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Kyoto Prefectural University of Medicine · JPFujita Health University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 62-year-old man exhibiting nasal obstruction and glomerulonephritis with proteinase 3-antineutrophil cytoplasmic antibodies (PR3-ANCAs) was diagnosed with extranodal NK/T-cell lymphoma, nasal type (ENKL) with infiltration of neutrophils with apoptosis. Chemoradiotherapy reduced the tumor, improved the renal function, and decreased the PR3-ANCA levels. ANCA-positivity is observed in immunoinsufficient diseases, in which neutrophils lead to apoptosis and translocate intracellular granules, such as PR3, to the cell surface, triggering the production of ANCAs. In our case, the PR3-ANCA production was derived from the expression of PR3 on the cell surface of apoptotic neutrophils. This is the first report on ENKL describing the mechanism of ANCA development.

Indexed as

Antibodies, Antineutrophil CytoplasmicAnti-Neutrophil Cytoplasmic Antibody-Associated VasculitisApoptosisDiagnosis, DifferentialGlomerulonephritisGranulomatosis with PolyangiitisHumansLymphoma, Extranodal NK-T-CellMaleMiddle AgedMyeloblastinNeutrophilsNose NeoplasmsAntibodies, Antineutrophil CytoplasmicMyeloblastinapoptosisextranodal NK/T-cell lymphomanasal typeneutrophilproteinase 3 antineutrophil cytoplasmic antibodies

Identifiers

PMID28768972
PMCPMC5577078
OpenAlexW2740095839

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.