ArticleJCI insight2017
Integration of homeostatic signaling and food reward processing in the human brain.
Article in JCI insight, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03081585 (Integration of Homeostatic Signaling and Food Reward Processing in the Human Brain), which is not on this map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Integration of Homeostatic Signaling and Food Reward Processing in the Human Brain
Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
- Blunted anticipation, but not consummation, of food rewards in depression.Cell reports. Medicine · 2026Article
- Article
- Appetite Self-Regulation in Childhood: A Narrative Review and Conceptual Model of Processes and Mechanisms With Implications for Research and Practice.Nutrition reviews · 2025Review
- Impaired maturation of resting-state connectivity in anorexia nervosa from adolescence to adulthood: differential mechanisms of consummatory vs. anticipatory responses through a symptom provocation paradigm.Frontiers in behavioral neuroscience · 2024Article
- The role of oestrogen in determining sexual dimorphism in energy balance.The Journal of physiology · 2023Review
- The interaction between depression diagnosis and BMI is related to altered activation pattern in the right inferior frontal gyrus and anterior cingulate cortex during food anticipation.Brain and behavior · 2022Article
- A Neuroeconomics Approach to Obesity.Biological psychiatry · 2022Review
- Diet as connecting factor: Functional brain connectivity in relation to food intake and sucrose tasting, assessed with resting-state functional MRI in rats.Journal of neuroscience research · 2022Article
- From "Hunger Hormone" to "It's Complicated": Ghrelin Beyond Feeding Control.Physiology (Bethesda, Md.) · 2022Review
- The role of reinforcement learning and value-based decision-making frameworks in understanding food choice and eating behaviors.Frontiers in nutrition · 2022Review
- Hunger improves reinforcement-driven but not planned action.Cognitive, affective & behavioral neuroscience · 2021Article
- Secondary rewards acquire enhanced incentive motivation via increasing anticipatory activity of the lateral orbitofrontal cortex.Brain structure & function · 2021Article
- The Hunger Games: Homeostatic State-Dependent Fluctuations in Disinhibition Measured with a Novel Gamified Test Battery.Nutrients · 2021Article
- Gastrointestinal Contributions to the Postprandial Experience.Nutrients · 2021Review
- Fasting may increase incentive signaling for nonfood rewards.Nutrition research (New York, N.Y.) · 2020Article
- Food, Eating, and the Gastrointestinal Tract.Nutrients · 2020Review
- Profound weight loss induces reactive astrogliosis in the arcuate nucleus of obese mice.Molecular metabolism · 2019Article
- Obesity, body weight regulation and the brain: insights from fMRI.The British journal of radiology · 2018Article
- Current perspectives on incentive salience and applications to clinical disorders.Current opinion in behavioral sciences · 2018Article
- Stress, Motivation, and the Gut-Brain Axis: A Focus on the Ghrelin System and Alcohol Use Disorder.Alcoholism, clinical and experimental research · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFood intake is guided by homeostatic needs and by the reward value of food, yet the exact relation between the two remains unclear. The aim of this study was to investigate the influence of different metabolic states and hormonal satiety signaling on responses in neural reward networks.
methodsTwenty-three healthy participants underwent functional magnetic resonance imaging while performing a task distinguishing between the anticipation and the receipt of either food- or monetary-related reward. Every participant was scanned twice in a counterbalanced fashion, both during a fasted state (after 24 hours fasting) and satiety. A functional connectivity analysis was performed to investigate the influence of satiety signaling on activation in neural reward networks. Blood samples were collected to assess hormonal satiety signaling.
resultsFasting was associated with sensitization of the striatal reward system to the anticipation of food reward irrespective of reward magnitude. Furthermore, during satiety, individual ghrelin levels were associated with increased neural processing during the expectation of food-related reward.
conclusionsOur findings show that physiological hunger stimulates food consumption by specifically increasing neural processing during the expectation (i.e., incentive salience) but not the receipt of food-related reward. In addition, these findings suggest that ghrelin signaling influences hedonic-driven food intake by increasing neural reactivity during the expectation of food-related reward. These results provide insights into the neurobiological underpinnings of motivational processing and hedonic evaluation of food reward.
trial registrationClinicalTrials.gov NCT03081585.
fundingThis work was supported by the German Competence Network on Obesity, which is funded by the German Federal Ministry of Education and Research (FKZ 01GI1122E).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.