ArticleNeurology2017
Association of parathyroid hormone with 20-year cognitive decline: The ARIC study.
Abstract readMulticenter Study
In one paragraph
Article in Neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The association between hypoparathyroidism and cognitive impairment: a systematic review.Journal of endocrinological investigation · 2021Pooled it
- Trial
- Neuropsychiatric manifestations of primary hyperparathyroidism.Wiener klinische Wochenschrift · 2026Review
- Potential Biological and Genetic Links Between Dementia and Osteoporosis: A Scoping Review.Geriatrics (Basel, Switzerland) · 2025Review
- Combined impact of neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and cognitive function on all-cause mortality in older adults: a population-based study.Lipids in health and disease · 2025Article
- Elevated HIF-1α levels in maintenance hemodialysis patients: a potential link to increased cognitive impairment risk.Frontiers in aging neuroscience · 2024Article
- Giant Parathyroid Adenoma: A Case Report.Cureus · 2023Article
- Subclinical cardiovascular disease and frailty risk: the atherosclerosis risk in communities study.BMC geriatrics · 2022Article
- Characteristics of movers and predictors of residential mobility in the Atherosclerosis Risk in Communities (ARIC) cohort.Health & place · 2022Article
- Cognition impairment and risk of subclinical cardiovascular disease in older adults: The atherosclerosis risk in communities study.Frontiers in aging neuroscience · 2022Article
- Successful parathyroidectomy improves cognition in patients with primary hyperparathyroidism: A prospective study in a tertiary medical center and comprehensive review of the literature.Frontiers in endocrinology · 2022Review
- Silent Myocardial Infarction and Long-Term Risk of Frailty: The Atherosclerosis Risk in Communities Study.Clinical interventions in aging · 2021Article
- Sex as a biological variable in the pathology and pharmacology of neurodegenerative and neurovascular diseases.British journal of pharmacology · 2019Review
- Relation of Elevated Resting Heart Rate in Mid-Life to Cognitive Decline Over 20 Years (from the Atherosclerosis Risk in Communities [ARIC] Study).The American journal of cardiology · 2019Article
- Decreased Levels of Serum IGF-1 and Vitamin D Are Associated With Cognitive Impairment in Patients With Type 2 Diabetes.American journal of Alzheimer's disease and other dementiasArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Samuel M KimFrom the Ciccarone Center for the Prevention of Heart Disease (S.M.K., E.D.M.) and Department of Neurology (A.L.C.S., R.F.G.), Johns Hopkins University School of Medicine; Department of Epidemiology (D.Z., E.G., R.F.G., E.D.M.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Northeast Ohio Medical University (S.K.K.), Rootstown; Division of Epidemiology and Community Health (P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (A.A.), Rollins School of Public Health, Emory University, Atlanta, GA; and Department of Medicine (B.G.W.), Division of Geriatrics, University of Mississippi Medical Center, Jackson.
Di ZhaoFrom the Ciccarone Center for the Prevention of Heart Disease (S.M.K., E.D.M.) and Department of Neurology (A.L.C.S., R.F.G.), Johns Hopkins University School of Medicine; Department of Epidemiology (D.Z., E.G., R.F.G., E.D.M.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Northeast Ohio Medical University (S.K.K.), Rootstown; Division of Epidemiology and Community Health (P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (A.A.), Rollins School of Public Health, Emory University, Atlanta, GA; and Department of Medicine (B.G.W.), Division of Geriatrics, University of Mississippi Medical Center, Jackson.
Andrea L C SchneiderFrom the Ciccarone Center for the Prevention of Heart Disease (S.M.K., E.D.M.) and Department of Neurology (A.L.C.S., R.F.G.), Johns Hopkins University School of Medicine; Department of Epidemiology (D.Z., E.G., R.F.G., E.D.M.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Northeast Ohio Medical University (S.K.K.), Rootstown; Division of Epidemiology and Community Health (P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (A.A.), Rollins School of Public Health, Emory University, Atlanta, GA; and Department of Medicine (B.G.W.), Division of Geriatrics, University of Mississippi Medical Center, Jackson.
Sai Krishna KoradaFrom the Ciccarone Center for the Prevention of Heart Disease (S.M.K., E.D.M.) and Department of Neurology (A.L.C.S., R.F.G.), Johns Hopkins University School of Medicine; Department of Epidemiology (D.Z., E.G., R.F.G., E.D.M.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Northeast Ohio Medical University (S.K.K.), Rootstown; Division of Epidemiology and Community Health (P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (A.A.), Rollins School of Public Health, Emory University, Atlanta, GA; and Department of Medicine (B.G.W.), Division of Geriatrics, University of Mississippi Medical Center, Jackson.
Pamela L LutseyFrom the Ciccarone Center for the Prevention of Heart Disease (S.M.K., E.D.M.) and Department of Neurology (A.L.C.S., R.F.G.), Johns Hopkins University School of Medicine; Department of Epidemiology (D.Z., E.G., R.F.G., E.D.M.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Northeast Ohio Medical University (S.K.K.), Rootstown; Division of Epidemiology and Community Health (P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (A.A.), Rollins School of Public Health, Emory University, Atlanta, GA; and Department of Medicine (B.G.W.), Division of Geriatrics, University of Mississippi Medical Center, Jackson.
Eliseo GuallarFrom the Ciccarone Center for the Prevention of Heart Disease (S.M.K., E.D.M.) and Department of Neurology (A.L.C.S., R.F.G.), Johns Hopkins University School of Medicine; Department of Epidemiology (D.Z., E.G., R.F.G., E.D.M.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Northeast Ohio Medical University (S.K.K.), Rootstown; Division of Epidemiology and Community Health (P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (A.A.), Rollins School of Public Health, Emory University, Atlanta, GA; and Department of Medicine (B.G.W.), Division of Geriatrics, University of Mississippi Medical Center, Jackson.
Alvaro AlonsoFrom the Ciccarone Center for the Prevention of Heart Disease (S.M.K., E.D.M.) and Department of Neurology (A.L.C.S., R.F.G.), Johns Hopkins University School of Medicine; Department of Epidemiology (D.Z., E.G., R.F.G., E.D.M.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Northeast Ohio Medical University (S.K.K.), Rootstown; Division of Epidemiology and Community Health (P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (A.A.), Rollins School of Public Health, Emory University, Atlanta, GA; and Department of Medicine (B.G.W.), Division of Geriatrics, University of Mississippi Medical Center, Jackson.
B Gwen WindhamFrom the Ciccarone Center for the Prevention of Heart Disease (S.M.K., E.D.M.) and Department of Neurology (A.L.C.S., R.F.G.), Johns Hopkins University School of Medicine; Department of Epidemiology (D.Z., E.G., R.F.G., E.D.M.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Northeast Ohio Medical University (S.K.K.), Rootstown; Division of Epidemiology and Community Health (P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (A.A.), Rollins School of Public Health, Emory University, Atlanta, GA; and Department of Medicine (B.G.W.), Division of Geriatrics, University of Mississippi Medical Center, Jackson.
Rebecca F GottesmanFrom the Ciccarone Center for the Prevention of Heart Disease (S.M.K., E.D.M.) and Department of Neurology (A.L.C.S., R.F.G.), Johns Hopkins University School of Medicine; Department of Epidemiology (D.Z., E.G., R.F.G., E.D.M.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Northeast Ohio Medical University (S.K.K.), Rootstown; Division of Epidemiology and Community Health (P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (A.A.), Rollins School of Public Health, Emory University, Atlanta, GA; and Department of Medicine (B.G.W.), Division of Geriatrics, University of Mississippi Medical Center, Jackson.
Erin D MichosFrom the Ciccarone Center for the Prevention of Heart Disease (S.M.K., E.D.M.) and Department of Neurology (A.L.C.S., R.F.G.), Johns Hopkins University School of Medicine; Department of Epidemiology (D.Z., E.G., R.F.G., E.D.M.), Johns Hopkins Bloomberg School of Public Health, Baltimore, MD; Northeast Ohio Medical University (S.K.K.), Rootstown; Division of Epidemiology and Community Health (P.L.L.), School of Public Health, University of Minnesota, Minneapolis; Department of Epidemiology (A.A.), Rollins School of Public Health, Emory University, Atlanta, GA; and Department of Medicine (B.G.W.), Division of Geriatrics, University of Mississippi Medical Center, Jackson. edonnell@jhmi.edu.
Northeast Ohio Medical University · USUniversity of Minnesota · USEmory University · USJohns Hopkins University · US
Funding
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7MARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9MARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5MARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4MARIC Neurocognitive Study (ARIC-NCS) Renewal 4 of 5U01HL096814 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HUGHES, TIMOTHY M., WAGENKNECHT, LYNNE E · 2010 to 2018
$6.5MVitamin D, cerebrovascular risk, and neurocognitive decline: ARIC Brain MRI StudyR01NS072243 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MICHOS, ERIN D · 2011 to 2014
$1.4MNHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096814NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NINDS NIH HHS R01 NS072243
Abstract
objectiveWe hypothesized that elevated parathyroid hormone (PTH) levels will be independently associated with 20-year cognitive decline in a large population-based cohort.
methodsWe studied 12,964 middle-aged white and black ARIC participants without a history of prior stroke who, in 1990-1992 (baseline), had serum PTH levels measured and cognitive function testing, with repeat cognitive testing performed at up to 2 follow-up visits. Cognitive testing included the Delayed Word Recall, the Digit Symbol Substitution, and the Word Fluency tests, which were summed as a global
resultsThe mean (SD) age of our cohort was 57 (6) years, 57% were women, and 24% were black. There was no cross-sectional association of elevated PTH with cognitive global
conclusionsOur work does not support an independent influence of PTH on cognitive decline in this population-based cohort study.
Indexed as
BiomarkersCognitive DysfunctionCross-Sectional StudiesFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsParathyroid HormoneProspective StudiesTime FactorsBiomarkersParathyroid Hormone
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.