ArticleMolecular biology of the cell2017
Sphingolipids facilitate age asymmetry of membrane proteins in dividing yeast cells.
Article in Molecular biology of the cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Sphingolipid and methionine metabolism in aging.Journal of cell science · 2025Review
- Cell membrane asymmetries and cellular aging.The Biochemical journal · 2025Review
- Up-regulation of the Cdc42 GTPase limits the replicative life span of budding yeast.Molecular biology of the cell · 2022Article
- Erg25 Controls Host-Cholesterol Uptake Mediated by Aus1p-Associated Sterol-Rich Membrane Domains inFrontiers in cell and developmental biology · 2022Article
- Understanding the Impact of Industrial Stress Conditions on Replicative Aging inFrontiers in fungal biology · 2021Review
- Solid-phase inclusion as a mechanism for regulating unfolded proteins in the mitochondrial matrix.Science advances · 2020Article
- Review
- Cell organelles and yeast longevity: an intertwined regulation.Current genetics · 2020Review
- Measuring the Replicative Lifespan of Saccharomyces cerevisiae Using the HYAA Microfluidic Platform.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Membrane Heterogeneity Beyond the Plasma Membrane.Frontiers in cell and developmental biology · 2020Review
- Seipin negatively regulates sphingolipid production at the ER-LD contact site.The Journal of cell biology · 2019Article
- Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry.Developmental cell · 2019Article
- Distinct segregation patterns of yeast cell-peripheral proteins uncovered by a method for protein segregatome analysis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Emerging roles for sphingolipids in cellular aging.Current genetics · 2018Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
One proposed mechanism of cellular aging is the gradual loss of certain cellular components that are insufficiently renewed. In an earlier study, multidrug resistance transporters (MDRs) were postulated to be such aging determinants during the yeast replicative life span (RLS). Aged MDR proteins were asymmetrically retained by the aging mother cell and did not diffuse freely into the bud, whereas newly synthesized MDR proteins were thought to be deposited mostly in the bud before cytokinesis. In this study, we further demonstrate the proposed age asymmetry of MDR proteins in dividing yeast cells and investigate the mechanism that controls diffusive properties of MDR proteins to maintain this asymmetry. We found that long-chain sphingolipids, but not the septin/endoplasmic reticulum-based membrane diffusion barrier, are important for restricting MDR diffusion. Depletion of sphingolipids or shortening of their long acyl chains resulted in an increase in the lateral mobility of MDR proteins, causing aged MDR protein in the mother cell to enter the bud. We used a mathematical model to understand the effect of diminished MDR age asymmetry on yeast cell aging, the result of which was qualitatively consistent with the observed RLS shortening in sphingolipid mutants.
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