ArticleJournal of neurointerventional surgery2018
Rabbit aneurysm models mimic histologic wall types identified in human intracranial aneurysms.
Article in Journal of neurointerventional surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preclinical extracranial aneurysm models for the study and treatment of brain aneurysms: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Pooled it
- An In vivo Pilot Study to Estimate the Swelling of the Aneurysm Wall Rabbit Model Generated with Pulsed Fluid Against the Aneurysm Wall.Annals of biomedical engineering · 2025Article
- Targeting myeloperoxidase to stabilize unruptured aneurysm: an imaging-guided approach.BMC cardiovascular disorders · 2024Article
- High wall shear stress-dependent podosome formation in a novel murine model of intracranial aneurysm.Frontiers in stroke · 2024Article
- Rabbit Elastase Aneurysm Model Mimics the Recurrence Rate of Human Intracranial Aneurysms following Platinum Coil Embolization.AJNR. American journal of neuroradiology · 2022Article
- Disturbed flow's impact on cellular changes indicative of vascular aneurysm initiation, expansion, and rupture: A pathological and methodological review.Journal of cellular physiology · 2022Review
- An Improved Surgical Technique to Increase Neck Width of Elastase-Induced Aneurysm Model in Rabbits: A Prospective Study.Frontiers in neurology · 2022Article
- In situ decellularization of a large animal saccular aneurysm model: sustained inflammation and active aneurysm wall remodeling.Journal of neurointerventional surgery · 2021Article
- Adaptive Remodeling in the Elastase-induced Rabbit Aneurysms.Experimental mechanics · 2021Article
- Structural Remodeling of the Extracellular Matrix in Arteriogenesis: A Review.Frontiers in cardiovascular medicine · 2021Review
- The development and understanding of intracranial aneurysm based on rabbit model.Neuroradiology · 2020Review
- Comparison of Aneurysm Patency and Mural Inflammation in an Arterial Rabbit Sidewall and Bifurcation Aneurysm Model under Consideration of Different Wall Conditions.Brain sciences · 2020Article
- Saccular Aneurysm Models Featuring Growth and Rupture: A Systematic Review.Brain sciences · 2020Review
- Assessment of endothelialization of aneurysm wall over time in a rabbit model through CD31 scoring.Journal of neurointerventional surgery · 2018Article
- Ruptured Fisher grade 3 blister aneurysms have a higher incidence of delayed cerebral ischemia than ruptured Fisher grade 3 saccular aneurysms.Brain circulationArticle
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Authors and funding
7 authors.
Funding
Abstract
backgroundSemiquantitative scales correlate histopathologic findings in the walls of human aneurysms with rupture status.
objectiveTo apply a semiquantitative scale to the rabbit elastase-induced aneurysm model to determine whether rabbit histologic types mimic the full range of histologic subtypes of humans. MATERIALS AND
methodsTwenty-seven elastase-induced female rabbit aneurysms were studied, harvested at 2 weeks (n=5) and 12 weeks (n=22). Paraffin-embedded sections received hematoxylin-eosin and Verhoeff-Van Gieson staining. Immunohistochemistry was performed for α-smooth muscle actin and CD31 for endothelial cells. A semiquantitative scale was used for scoring based on human aneurysm tissue, divided into four subtypes according to cellular and extracellular matrix findings: type A, linear organized smooth muscle cells (SMCs) and intact endothelium; type B, thickened wall with disorganized, proliferating SMCs; type C, thick, collagenized and hypocellular wall with or without organizing thrombosis, and type D, extremely thin, hypocellular wall. Separate scoring was performed of the aneurysm neck and proximal and distal zones.
resultsFindings compatible with all subtypes of human aneurysm tissue were identified. Types A and C were found in 13 (48%) and 11 (41%) of 27 aneurysms and in the proximal and distal wall at both time points. Type B was found in 16 aneurysms (59%), exclusively at the neck at both time points; type D, in 14 aneurysms (52%), exclusively at proximal and distal zones of 12-week aneurysms.
conclusionsThe wall of elastase-induced rabbit aneurysm demonstrates histologic findings similar to the four categories of human cerebral aneurysms based on cellular and extracellular wall content.
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