Evidence map›Paper›PMID 28768811›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Conformational and chemical selection by a

Eric M Danhart, Marina Bakhtina, William A Cantara, Alexandra B Kuzmishin, Xiao Ma, Brianne L Sanford, Oscar Vargas-Rodriguez, Marija Košutić, Yuki Goto, Hiroaki Suga and 4 more

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  6. Review
  7. Frontiers in microbiology · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. HumanThe Journal of biological chemistry · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 3 countries.

Eric M DanhartDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
Marina BakhtinaDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
William A CantaraDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
Alexandra B KuzmishinDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
Xiao MaDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
Brianne L SanfordDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
Oscar Vargas-Rodriguez
Marija KošutićInstitute of Organic Chemistry, Leopold Franzens University, A-6020 Innsbruck, Austria.
Yuki GotoDepartment of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.
Hiroaki SugaDepartment of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan.
Kotaro NakanishiDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210.
Ronald MicuraInstitute of Organic Chemistry, Leopold Franzens University, A-6020 Innsbruck, Austria.
Mark P FosterDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210; foster.281@osu.edu musier-forsyth.1@osu.edu.ORCID 0000-0001-9645-7491
Karin Musier-ForsythDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH 43210; foster.281@osu.edu musier-forsyth.1@osu.edu.
The Ohio State University · USBiocrates Life Sciences (Austria) · ATThe University of Tokyo · JP

Funding

CLASS II AMINOACYL-TRNA SYNTHETASE SUBSTRATE RECOGNITIONR01GM049928 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI MUSIER-FORSYTH, KARIN M · 1996 to 2012
$4.0M
CHEMISTRY/BIOLOGY TRAINING GRANTT32GM008512 · NIGMS · OHIO STATE UNIVERSITY · PI PEI, DEHUA · 1996 to 2016
$3.9M
Translational quality control by trans-editing domainsR01GM113656 · NIGMS · OHIO STATE UNIVERSITY · PI MUSIER-FORSYTH, KARIN M · 2015 to 2018
$1.1M
NIGMS NIH HHS R01 GM049928NIGMS NIH HHS R01 GM113656NIGMS NIH HHS T32 GM008512
6 · The paper itself

Abstract

Molecular sieves ensure proper pairing of tRNAs and amino acids during aminoacyl-tRNA biosynthesis, thereby avoiding detrimental effects of mistranslation on cell growth and viability. Mischarging errors are often corrected through the activity of specialized editing domains present in some aminoacyl-tRNA synthetases or via single-domain

Indexed as

Amino AcidsAmino Acyl-tRNA SynthetasesBacterial ProteinsBinding SitesCaulobacter crescentusCrystallography, X-RayModels, MolecularMutagenesis, Site-DirectedNucleic Acid ConformationProtein BiosynthesisProtein ConformationRNA EditingRNA, Transfer, ProSubstrate SpecificityAmino AcidsAmino Acyl-tRNA SynthetasesBacterial Proteinsprolyl T RNA synthetaseRNA, Transfer, Proaminoacyl-tRNA synthetasesconformational selectionmolecular dynamicsNMRtrans-editing

Identifiers

PMID28768811
PMCPMC5565427
OpenAlexW2740721978

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.