Evidence map›Paper›PMID 28768768›Full record

ArticleThe Journal of biological chemistry2017

Regulation of the epithelial Na

Shujie Shi, Teresa M Buck, Carol L Kinlough, Allison L Marciszyn, Rebecca P Hughey, Martin Chalfie, Jeffrey L Brodsky, Thomas R Kleyman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

  1. Paraoxonase 3 regulates the pore-forming α subunit of the large-conductance KBiochimica et biophysica acta. Molecular cell research · 2025
    Article
  2. Epithelial NaComprehensive Physiology · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Paraoxonase 2 is an ER chaperone that regulates the epithelial NaAmerican journal of physiology. Cell physiology · 2022
    Article
  7. DEG/ENaC Ion Channels in the Function of the Nervous System: From Worm to Man.Advances in experimental medicine and biology · 2021
    Article
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Shujie ShiFrom the Renal-Electrolyte Division, Department of Medicine.
Teresa M BuckDepartment of Biological Sciences.
Carol L KinloughFrom the Renal-Electrolyte Division, Department of Medicine.
Allison L MarciszynFrom the Renal-Electrolyte Division, Department of Medicine.
Rebecca P HugheyFrom the Renal-Electrolyte Division, Department of Medicine.
Martin Chalfiethe Department of Biological Sciences, Columbia University, New York, New York 10027.
Jeffrey L BrodskyDepartment of Biological Sciences.
Thomas R KleymanFrom the Renal-Electrolyte Division, Department of Medicine, kleyman@pitt.edu.
Renal Association · GBColumbia University · USInstitute of Cell Biology · UAUniversity of Pittsburgh · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L · 2008 to 2022
$13.4M
GENETIC ANALYSIS OF NEMATODE CELL DIFFERENTIATIONR01GM030997 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHALFIE, MARTIN · 1985 to 2017
$7.1M
GENETIC ANALYSIS OF NEMATODE CELL DIFFERENTIATIONR37GM030997 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHALFIE, MARTIN · 1999 to 2009
$6.6M
Genetic analysis of nematode cell differentiationR35GM122522 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MARTIN CHALFIE · 2017 to 2026
$6.5M
Biomechanical Regulation of Renal Ion TransportersR37DK051391 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2006 to 2015
$3.2M
ER Associated Degradation of Membrane Proteins in YeastR01GM075061 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRODSKY, JEFFREY L. · 2006 to 2019
$3.2M
SODIUM CHANNELS IN THE MAMMALIAN URINARY BLADDERR01DK051391 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R. · 1996 to 2005
$1.5M
Regulation of ENaC/degenerin channels by mechanical forcesK01DK103834 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHI, SHUJIE · 2014 to 2018
$688k
Characterization of the ER associated Biogenesis and Degradation of ENaCK01DK090195 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUCK, TERESA M · 2011 to 2015
$497k
NIDDK NIH HHS K01 DK090195NIDDK NIH HHS K01 DK103834NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK051391NIDDK NIH HHS R37 DK051391NIGMS NIH HHS R01 GM030997NIGMS NIH HHS R01 GM075061NIGMS NIH HHS R35 GM122522NIGMS NIH HHS R37 GM030997
6 · The paper itself

Abstract

Paraoxonase-2 (PON-2) is a membrane-bound lactonase with unique anti-oxidative and anti-atherosclerotic properties. PON-2 shares key structural elements with MEC-6, an endoplasmic reticulum-resident molecular chaperone in

Indexed as

AdultAnimalsAryldialkylphosphataseCaenorhabditis elegans ProteinsConserved SequenceEpithelial Sodium ChannelsEvolution, MolecularGene Expression RegulationHEK293 CellsHumansKidney Tubules, DistalMiceOocytesProtein SubunitsRatsAryldialkylphosphataseCaenorhabditis elegans ProteinsEpithelial Sodium ChannelsMEC-6 protein, C elegansPON1 protein, humanPON2 protein, humanProtein Subunitsaldosterone sensitive distal nephronCaenorhabditis elegans (C. elegans)epithelial sodium channel (ENaC)lactonasemolecular chaperoneParaoxonasesodium channelXenopus

Identifiers

PMID28768768
PMCPMC5612122
OpenAlexW2739868843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.