ArticleJournal of neurophysiology2017
Theta-frequency selectivity in the somatic spike-triggered average of rat hippocampal pyramidal neurons is dependent on HCN channels.
Article in Journal of neurophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Intrinsic Excitability of Rat Hippocampal Granule Cells Increases Along the Dorsal-to-Ventral Axis.Hippocampus · 2026Article
- Functional transition of CA2 pyramidal neurons along the proximodistal axis determines resonance frequency preference.Scientific reports · 2026Article
- Review
- Morpho-electric diversity of human hippocampal CA1 pyramidal neurons.Cell reports · 2024Article
- Missing Puzzle Pieces in Dementia Research: HCN Channels and Theta Oscillations.Aging and disease · 2024Review
- Simulations predict differing phase responses to excitation vs. inhibition in theta-resonant pyramidal neurons.Journal of neurophysiology · 2023Article
- The impact of Hodgkin-Huxley models on dendritic research.The Journal of physiology · 2023Review
- Article
- Inspiratory rhythm generation is stabilized byJournal of neurophysiology · 2022Article
- Active Dendrites and Local Field Potentials: Biophysical Mechanisms and Computational Explorations.Neuroscience · 2022Review
- Spatial information transfer in hippocampal place cells depends on trial-to-trial variability, symmetry of place-field firing, and biophysical heterogeneities.Neural networks : the official journal of the International Neural Network Society · 2021Article
- Ion-channel degeneracy: Multiple ion channels heterogeneously regulate intrinsic physiology of rat hippocampal granule cells.Physiological reports · 2021Article
- Article
- Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences.Nature communications · 2021Article
- Emergent Elements of Inspiratory Rhythmogenesis: Network Synchronization and Synchrony Propagation.Neuron · 2020Article
- Robust emergence of sharply tuned place-cell responses in hippocampal neurons with structural and biophysical heterogeneities.Brain structure & function · 2020Article
- Heterogeneities in intrinsic excitability and frequency-dependent response properties of granule cells across the blades of the rat dentate gyrus.Journal of neurophysiology · 2020Article
- Degeneracy in the emergence of spike-triggered average of hippocampal pyramidal neurons.Scientific reports · 2020Article
- Optimization of Efficient Neuron Models With Realistic Firing Dynamics. The Case of the Cerebellar Granule Cell.Frontiers in cellular neuroscience · 2020Article
- A Model of Memory Linking Time to Space.Frontiers in computational neuroscience · 2020Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The ability to distill specific frequencies from complex spatiotemporal patterns of afferent inputs is a pivotal functional requirement for neurons residing in networks receiving frequency-multiplexed inputs. Although the expression of theta-frequency subthreshold resonance is established in hippocampal pyramidal neurons, it is not known if their spike initiation dynamics manifest spectral selectivity, or if their intrinsic properties are tuned to process gamma-frequency inputs. Here, we measured the spike-triggered average (STA) of rat hippocampal pyramidal neurons through electrophysiological recordings and quantified spectral selectivity in their spike initiation dynamics and their coincidence detection window (CDW). Our results revealed strong theta-frequency selectivity in the STA, which was also endowed with gamma-range CDW, with prominent neuron-to-neuron variability that manifested distinct pairwise dissociations and correlations with different intrinsic measurements. Furthermore, we demonstrate that the STA and its measurements substantially adapted to the state of the neuron defined by its membrane potential and to the statistics of its afferent inputs. Finally, we tested the effect of pharmacologically blocking the hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels on the STA and found that the STA characteristic frequency reduced significantly to the delta-frequency band after HCN channel blockade. This delta-frequency selectivity in the STA emerged in the absence of subthreshold resonance, which was abolished by HCN channel blockade, thereby confirming computational predictions on the dissociation between these two forms of spectral selectivity. Our results expand the roles of HCN channels to theta-frequency selectivity in the spike initiation dynamics, apart from underscoring the critical role of interactions among different ion channels in regulating neuronal physiology.
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