Evidence map›Paper›PMID 28768722›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

Macrophage migration inhibitory factor enhances

Aisling Tynan, Leona Mawhinney, Michelle E Armstrong, Ciaran O'Reilly, Sarah Kennedy, Emma Caraher, Karen Jülicher, David O'Dwyer, Lewena Maher, Kirsten Schaffer and 7 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Aisling TynanDepartment of Medicine, Tallaght Hospital, Trinity College, Dublin, Ireland.
Leona MawhinneyDepartment of Medicine, Tallaght Hospital, Trinity College, Dublin, Ireland.
Michelle E ArmstrongDepartment of Medicine, Tallaght Hospital, Trinity College, Dublin, Ireland.
Ciaran O'ReillyDepartment of Medicine, Tallaght Hospital, Trinity College, Dublin, Ireland.
Sarah KennedyDepartment of Science, Centre for Microbial Host Interactions, Institute of Technology Tallaght, Dublin, Ireland.
Emma CaraherDepartment of Science, Centre for Microbial Host Interactions, Institute of Technology Tallaght, Dublin, Ireland.
Karen JülicherDepartment of Medicine, Tallaght Hospital, Trinity College, Dublin, Ireland.
David O'DwyerSt. Vincent's University Hospital, University College Dublin, Dublin, Ireland.
Lewena MaherSt. Vincent's University Hospital, University College Dublin, Dublin, Ireland.
Kirsten SchafferSt. Vincent's University Hospital, University College Dublin, Dublin, Ireland.
Aurélie FabreSt. Vincent's University Hospital, University College Dublin, Dublin, Ireland.
Edward F McKoneSt. Vincent's University Hospital, University College Dublin, Dublin, Ireland.
Lin LengInternal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Richard BucalaInternal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Jürgen BernhagenInstitute of Biochemistry and Molecular Cell Biology, RWTH Aachen University, Aachen, Germany.
Gordon CookeDepartment of Science, Centre for Microbial Host Interactions, Institute of Technology Tallaght, Dublin, Ireland.
Seamas C DonnellyDepartment of Medicine, Tallaght Hospital, Trinity College, Dublin, Ireland; seamas.donnelly@tcd.ie.

Funding

Aging and Innate Immune Mechanisms in Pulmonary InfectionR01HL130669 · NHLBI · YALE UNIVERSITY · PI BUCALA, RICHARD J, GOLDSTEIN, DANIEL ROBERT · 2015 to 2018
$1.7M
NHLBI NIH HHS R01 HL130669
6 · The paper itself

Abstract

Macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator that we have previously shown to be associated with an aggressive clinical phenotype in cystic fibrosis. It possesses unique tautomerase enzymatic activity. However, to date, no human-derived substrate has been identified that has the capacity to interact with this cytokine's unique tautomerase activity. This led us to hypothesize that MIF may have the capacity to interact with external substrates. We describe for the first time how

Indexed as

AnimalsBiofilmsCystic FibrosisDisease Models, AnimalIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMicePseudomonas aeruginosaRecombinant ProteinsTobramycinIntramolecular OxidoreductasesMacrophage Migration-Inhibitory FactorsMIF protein, humanMif protein, mouseRecombinant ProteinsTobramycinbacteriacytokinerespiratory infections

Identifiers

PMID28768722
PMCPMC6159708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.