ArticleThe EMBO journal2017
Formin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia.
Open access · hybridAbstract read
In one paragraph
Article in The EMBO journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Plasma Biomarkers for Alzheimer's Disease Across the Continuum: A Systematic Review of SIMOA-Based Studies.Cellular and molecular neurobiology · 2026Pooled it
- The Insulin-like Growth Factor Family as a Potential Peripheral Biomarker in Psychiatric Disorders: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Genome-wide association study meta-analysis of neurofilament light (NfL) levels in blood reveals novel loci related to neurodegeneration.Communications biology · 2024Pooled it
- Reduced Plasma Aβ Peptides but Stable NfL and GFAP in Major Depressive Disorder.International journal of molecular sciences · 2026Article
- Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development.Neurobiology of disease · 2024Article
- Actomyosin organelle functions of SPIRE actin nucleators precede animal evolution.Communications biology · 2024Article
- Update on neurobiological mechanisms of fear: illuminating the direction of mechanism exploration and treatment development of trauma and fear-related disorders.Frontiers in behavioral neuroscience · 2023Review
- Transcriptome Profile in the Mouse Brain of Hepatic Encephalopathy and Alzheimer's Disease.International journal of molecular sciences · 2022Article
- Antagonistic Activities of Fmn2 and ADF Regulate Axonal F-Actin Patch Dynamics and the Initiation of Collateral Branching.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- A Role for Histone Deacetylases in the Biology and Treatment of Post-Traumatic Stress Disorder: What Do We Know and Where Do We Go from Here?Complex psychiatry · 2022Review
- Insulin-like Growth Factor 2 (IGF-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7) Are Upregulated after Atypical Antipsychotics in Spanish Schizophrenia Patients.International journal of molecular sciences · 2022Article
- A microRNA signature that correlates with cognition and is a target against cognitive decline.EMBO molecular medicine · 2021Article
- Formins in Human Disease.Cells · 2021Review
- Exosomes: Potential Disease Biomarkers and New Therapeutic Targets.Biomedicines · 2021Review
- Epigenetic gene expression links heart failure to memory impairment.EMBO molecular medicine · 2021Article
- MicroRNAs as Candidate Biomarkers for Alzheimer's Disease.Non-coding RNA · 2021Review
- An epigenome-wide association study of Alzheimer's disease blood highlights robust DNA hypermethylation in the HOXB6 gene.Neurobiology of aging · 2020Article
- Shared genetic etiology underlying late-onset Alzheimer's disease and posttraumatic stress syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020Article
- Molecular linkage between post-traumatic stress disorder and cognitive impairment: a targeted proteomics study of World Trade Center responders.Translational psychiatry · 2020Article
- Rab27a co-ordinates actin-dependent transport by controlling organelle-associated motors and track assembly proteins.Nature communications · 2020Article
Corrections and comments
- Commented on by
Authors and funding
20 authors at 10 institutions in 6 countries.
Roberto Carlos Agís-BalboaDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany.ORCID 0000-0001-9899-9569
Paulo S PinheiroInterdisciplinary Institute for Neuroscience, University of Bordeaux, Bordeaux, France.
Nelson RebolaInterdisciplinary Institute for Neuroscience, University of Bordeaux, Bordeaux, France.
Cemil KerimogluDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany.
Eva BenitoDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany.
Michael GertigDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany.
Sanaz Bahari-JavanDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Gaurav JainDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany.
Susanne BurkhardtDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany.
Ivana DelalleDepartment of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.
Alexander JatzkoDepartment of Psychosomatics, Westpfalzklinikum-Kaiserslautern, Teaching Hospital, University of Mainz, Mainz, Germany.
Markus DettenhoferCEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.ORCID 0000-0003-1972-7026
Patricia A ZunszainStress, Psychiatry and Immunology Laboratory, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Andrea SchmittDepartment of Psychiatry and Psychotherapy, LMU Munich, Munich, Germany.
Peter FalkaiDepartment of Psychiatry and Psychotherapy, LMU Munich, Munich, Germany.
Julius C PapeDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Elisabeth B BinderDepartment of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
Christophe MulleInterdisciplinary Institute for Neuroscience, University of Bordeaux, Bordeaux, France.
Andre FischerDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany andre.fischer@dzne.de farahnaz.sananbenesi@dzne.de.ORCID 0000-0001-8546-1161
Farahnaz SananbenesiDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany andre.fischer@dzne.de farahnaz.sananbenesi@dzne.de.ORCID 0000-0002-2123-7694
German Center for Neurodegenerative Diseases · DEBoston University · USCentre National de la Recherche Scientifique · FRMax Planck Institute of Psychiatry · DECentral European Institute of Technology · CZJohannes Gutenberg University Mainz · DEKing's College London · GBLMU Klinikum · DEUniversidade de São Paulo · BRUniversitätsmedizin Göttingen · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-associated memory decline is due to variable combinations of genetic and environmental risk factors. How these risk factors interact to drive disease onset is currently unknown. Here we begin to elucidate the mechanisms by which post-traumatic stress disorder (PTSD) at a young age contributes to an increased risk to develop dementia at old age. We show that the actin nucleator Formin 2 (
Indexed as
AdultAge of OnsetAgingAnimalsCase-Control StudiesDementiaForminsHumansMaleMemoryMiceMice, KnockoutMicrofilament ProteinsMiddle AgedNerve Tissue ProteinsNeuronal Plasticityformin 2 protein, mouseForminsMicrofilament ProteinsNerve Tissue ProteinsNuclear ProteinsagingAlzheimer's diseaseFormin 2HDAC inhibitorpost‐traumatic stress disorder
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.