Evidence map›Paper›PMID 28768707›Full record

ReviewClinical microbiology reviews2017

Impact of Childhood Malnutrition on Host Defense and Infection.

Marwa K Ibrahim, Mara Zambruni, Christopher L Melby, Peter C Melby

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinical microbiology reviews, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05183789 (Serum Levels of Interleukins 6 and 8 in Malnourished Children With Acute Diarrhea), which is not on this map. Cited by 160 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
160citing papers in PubMed, 5 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05183789 unknown statusnot on this mapstarted 2022, after this paper: background citation

Serum Levels of Interleukins 6 and 8 in Malnourished Children With Acute Diarrhea

TypeobservationalSponsorSohag UniversityRan2022 to 2023Enrolled60ConditionsAcute Diarrhea, Severe Acute Malnutrition, Acute GastroenteritisArmsEvaluation of serum levels of IL-6 and IL-8
3 · Its place in the literature

Who cites it

160 citing papers in PubMed, 5 syntheses or guidelines pooled it, 335 citations in OpenAlex.

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  14. Climate change and antimicrobial resistance.Nature reviews. Microbiology · 2026
    Review
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100 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Marwa K IbrahimDepartment of Microbial Biotechnology, Genetic Engineering Division, National Research Center, Giza, Egypt.
Mara ZambruniDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA.
Christopher L MelbyDepartment of Food Science and Human Nutrition, Colorado State University, Ft. Collins, Colorado, USA.
Peter C MelbyDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas, USA pcmelby@utmb.edu.
The University of Texas Medical Branch at Galveston · USColorado State University · USNational Research Centre · EG

Funding

Mechanisms of Parasite Dissemination in Visceral LeishmaniasisR01AI130126 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MELBY, PETER C. · 2018 to 2022
$2.8M
Malnutrition-related Lymph Node Dysfunction and Risk of Visceral LeishmaniasisR21AI107419 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MELBY, PETER C. · 2014 to 2015
$426k
NIAID NIH HHS R01 AI130126NIAID NIH HHS R21 AI107419
6 · The paper itself

Abstract

The global impact of childhood malnutrition is staggering. The synergism between malnutrition and infection contributes substantially to childhood morbidity and mortality. Anthropometric indicators of malnutrition are associated with the increased risk and severity of infections caused by many pathogens, including viruses, bacteria, protozoa, and helminths. Since childhood malnutrition commonly involves the inadequate intake of protein and calories, with superimposed micronutrient deficiencies, the causal factors involved in impaired host defense are usually not defined. This review focuses on literature related to impaired host defense and the risk of infection in primary childhood malnutrition. Particular attention is given to longitudinal and prospective cohort human studies and studies of experimental animal models that address causal, mechanistic relationships between malnutrition and host defense. Protein and micronutrient deficiencies impact the hematopoietic and lymphoid organs and compromise both innate and adaptive immune functions. Malnutrition-related changes in intestinal microbiota contribute to growth faltering and dysregulated inflammation and immune function. Although substantial progress has been made in understanding the malnutrition-infection synergism, critical gaps in our understanding remain. We highlight the need for mechanistic studies that can lead to targeted interventions to improve host defense and reduce the morbidity and mortality of infectious diseases in this vulnerable population.

Indexed as

MalnutritionAnimalsCommunicable DiseasesDisease SusceptibilityHumansImmune SystemProspective StudiesRisk Factorshost defenseimmunologyinfectious diseasemalariamalnutritionmicronutrientsMycobacterium tuberculosispneumoniasepsis

Identifiers

PMID28768707
PMCPMC5608884
OpenAlexW2741804227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.