SynthesisJournal of the American Heart Association2017
Inflammatory Bowel Disease and Risk of Ischemic Heart Disease: An Updated Meta-Analysis of Cohort Studies.
Synthesis in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Risk of stroke in patients with inflammatory bowel disease: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Inflammatory bowel disease patients have an increased risk of acute coronary syndrome: a systematic review and meta-analysis.Open heart · 2023Pooled it
- Rising Burden and Clinical Impact of Metabolic Syndrome in Inflammatory Bowel Disease: A Real-World Cohort Study.United European gastroenterology journal · 2026Article
- Impact of Inflammatory Disorders on Outcomes in Acute Heart Failure: A Nationwide Analysis.Cardiology · 2026Article
- Extra-Virgin Olive Oil Phenolics in IBD-Associated Vascular Risk.Molecules (Basel, Switzerland) · 2026Review
- From Inflammation to Thrombosis: The Prothrombotic State and Cardiovascular Risk in Inflammatory Bowel Disease.Medicina (Kaunas, Lithuania) · 2026Review
- Heart Under Pressure: Divergent Cardiac Molecules Responses to Azathioprine and Anti-TNF Therapy in Ulcerative Colitis.International journal of molecular sciences · 2025Observational
- Cardiovascular Complications Are Increased in Inflammatory Bowel Disease: A Path Toward Achievement of a Personalized Risk Estimation.Journal of personalized medicine · 2025Article
- Cardiovascular complications during delivery hospitalizations in inflammatory bowel disease patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Cardiovascular magnetic resonance reveals myocardial involvement in patients with active stage of inflammatory bowel disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Observational
- Cellular and Molecular Mechanisms Explaining the Link Between Inflammatory Bowel Disease and Heart Failure.Cells · 2025Review
- Advanced biologic therapies and cardiovascular events in patients with inflammatory bowel disease.American journal of preventive cardiology · 2025Article
- Management of Atherosclerotic Cardiovascular Risk in Inflammatory Bowel Disease: Current Perspectives.Advances in therapy · 2025Review
- Inflammatory bowel disease is associated with an increased risk of cardiovascular events in a sex and age-dependent manner: A historical cohort study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Leaky gut in systemic inflammation: exploring the link between gastrointestinal disorders and age-related diseases.GeroScience · 2025Review
- Identifying Risk Factors of Major Adverse Cardiac Events in Patients With Ulcerative Colitis: A Retrospective Japanese Claims Data Analysis.Journal of gastroenterology and hepatology · 2025Article
- Thromboembolic and cardiovascular risk profiles in patients with ulcerative colitis initiating advanced therapies.Therapeutic advances in gastroenterology · 2025Article
- Volume and distribution of white matter hyperintensities in rheumatoid arthritis and ulcerative colitis patients.Scientific reports · 2024Article
- Exploring the Link Between Genetic Predictors of Cardiovascular Disease and Psoriasis.JAMA cardiology · 2024Article
- Inflammatory Bowel Disease and Cardiovascular Disease.Gastroenterology & hepatology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral immune-mediated diseases have been shown to be associated with an increased risk of cardiovascular disease. However, studies evaluating the association between inflammatory bowel disease and risk of cardiovascular disease reported inconsistent results. We assessed the association between inflammatory bowel disease and risk of ischemic heart disease in a meta-analysis of cohort studies. METHODS AND
resultsWe conducted a literature search of PubMed and Embase up to October 2016 to identify relevant studies. The summary relative risks were calculated using the random-effects models. To explore the source of heterogeneity, we performed subgroup and sensitivity analysis. We included 10 cohort studies that satisfied our inclusion criteria
conclusionsBased on meta-analysis of cohort studies, we found an increased risk of ischemic heart disease in patients with inflammatory bowel disease. Large long-term prospective studies are warranted to confirm our results.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.