ArticleBMC genomics2017
Comparative genomic analysis and characterization of incompatibility group FIB plasmid encoded virulence factors of Salmonella enterica isolated from food sources.
Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 40 citations in OpenAlex.
- A nutritional link to antimicrobial resistance: iron scarcity promotes plasmid co-selection inApplied and environmental microbiology · 2026Article
- Convergence of plasmid-driven virulence and antibiotic resistance in Escherichia coli.Nature communications · 2025Article
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- Complete genome sequences of 17Microbiology resource announcements · 2024Article
- Hypervirulent Capsular Serotypes K1 and K2International journal of molecular sciences · 2024Article
- Versatile allelic replacement and self-excising integrative vectors for plasmid genome mutation and complementation.Microbiology spectrum · 2024Article
- Antimicrobial Resistance and Genomic Characterization ofTransboundary and emerging diseases · 2024Article
- Genetic relatedness and virulence potential ofFrontiers in microbiology · 2024Article
- Genomic Insights into the First Emergence ofInfection and drug resistance · 2024Article
- Development of an antimicrobial resistance plasmid transfer gene database for enteric bacteria.Frontiers in bioinformatics · 2023Article
- Antimicrobial Resistance and Increased Virulence ofMicroorganisms · 2022Article
- Characterisation ofInternational journal of environmental research and public health · 2022Article
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- Genetic diversity and evolution of the virulence plasmids encoding aerobactin and salmochelin inVirulence · 2021Article
- Genetic Characterization ofMicroorganisms · 2021Article
- Virulence Comparison ofMicroorganisms · 2021Article
- Expression of Genes Located on the Incompatibility Group FIB Plasmids at Transcription and Protein Levels in Iron-Modified Growth Conditions.Frontiers in microbiology · 2021Article
- Current knowledge and perspectives of potential impacts of Salmonella enterica on the profile of the gut microbiota.BMC microbiology · 2020Review
- Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe degree to which the chromosomal mediated iron acquisition system contributes to virulence of many bacterial pathogens is well defined. However, the functional roles of plasmid encoded iron acquisition systems, specifically Sit and aerobactin, have yet to be determined for Salmonella spp. In a recent study, Salmonella enterica strains isolated from different food sources were sequenced on the Illumina MiSeq platform and found to harbor the incompatibility group (Inc) FIB plasmid. In this study, we examined sequence diversity and the contribution of factors encoded on the IncFIB plasmid to the virulence of S. enterica.
resultsWhole genome sequences of seven S. enterica isolates were compared to genomes of serovars of S. enterica isolated from food, animal, and human sources. SeqSero analysis predicted that six strains were serovar Typhimurium and one was Heidelberg. Among the S. Typhimurium strains, single nucleotide polymorphism (SNP)-based phylogenetic analyses revealed that five of the isolates clustered as a single monophyletic S. Typhimurium subclade, while one of the other strains branched with S. Typhimurium from a bovine source. DNA sequence based phylogenetic diversity analyses showed that the IncFIB plasmid-encoded Sit and aerobactin iron acquisition systems are conserved among bacterial species including S. enterica. The IncFIB plasmid was transferred to an IncFIB plasmid deficient strain of S. enterica by conjugation. The transconjugant SE819::IncFIB persisted in human intestinal epithelial (Caco-2) cells at a higher rate than the recipient SE819. Genes of the Sit and aerobactin operons in the IncFIB plasmid were differentially expressed in iron-rich and iron-depleted growth media.
conclusionsMinimal sequence diversity was detected in the Sit and aerobactin operons in the IncFIB plasmids present among different bacterial species, including foodborne Salmonella strains. IncFIB plasmid encoded factors play a role during infection under low-iron conditions in host cells.
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