Evidence map›Paper›PMID 28768426›Full record

ArticleAnnals of the Royal College of Surgeons of England2017

Necrotising fasciitis in a patient treated with FOLFIRI-aflibercept for colorectal cancer: a case report.

A Gonzaga-López, J Muñoz-Rodriguez, A Ruiz-Casado

Abstract readCase Reports
In one paragraph

Article in Annals of the Royal College of Surgeons of England, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

A Gonzaga-LópezMedical oncologist at Elda University Hospital.
J Muñoz-RodriguezGeneral surgeon at Puerta de Hierro Majadahonda University Hospital.
A Ruiz-CasadoMedical oncologist at Puerta de Hierro Majadahonda University Hospital.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-angiogenics have become an important part of the treatment of several types of tumours such as ovarian, breast, lung and colorectal cancer. Necrotising fasciitis has been reported with bevacizumab but no cases have been reported with aflibercept, ramucirumab or regorafenib in patients with colorectal cancer. Necrotising fasciitis is a rare complication affecting one in 5000 bevacizumab users. We report the case of a 64-year-old man with stage IV rectosigmoid cancer under treatment with folinic acid, fluorouracil and irinotecan (FOLFIRI) and aflibercept, who developed a Fournier's gangrene.

Indexed as

Antineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsColorectal NeoplasmsFasciitis, NecrotizingReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsBevacizumabCamptothecinFatal OutcomeFluorouracilFournier GangreneHumansLeucovorinMaleMiddle AgedafliberceptAntineoplastic AgentsBevacizumabCamptothecinFluorouracilLeucovorinReceptors, Vascular Endothelial Growth FactorRecombinant Fusion ProteinsAfliberceptAngiogenesis inhibitorBevacizumabColorectal neoplasmsNecrotising fasciitis

Identifiers

PMID28768426
PMCPMC5696931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.