Evidence map›Paper›PMID 28768416›Full record

ArticleJournal of the American Chemical Society2017

Manganese and Cobalt in the Nonheme-Metal-Binding Site of a Biosynthetic Model of Heme-Copper Oxidase Superfamily Confer Oxidase Activity through Redox-Inactive Mechanism.

Julian H Reed, Yelu Shi, Qianhong Zhu, Saumen Chakraborty, Evan N Mirts, Igor D Petrik, Ambika Bhagi-Damodaran, Matthew Ross, Pierre Moënne-Loccoz, Yong Zhang and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  4. Trace Elements in Medicinal Metallomics.Mini reviews in medicinal chemistry · 2025
    Review
  5. One-Electron NO to NChemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Review
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  11. Article
  12. Article
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  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Yelu ShiDepartment of Biomedical Engineering, Chemistry, and Biological Sciences, Stevens Institute of Technology , Hoboken, New Jersey 07030, United States.
Qianhong ZhuDivision of Environmental & Biomolecular Systems, Institute of Environmental Health, Oregon Health & Science University , Portland, Oregon 97239, United States.
Saumen ChakrabortyDepartment of Chemistry & Biochemistry, University of Mississippi , Oxford, Mississippi 38677, United States.ORCID 0000-0002-9256-2769
Evan N Mirts
Igor D Petrik
Ambika Bhagi-DamodaranDepartment of Pharmaceutical Chemistry, University of California, San Francisco , San Francisco, California 94143, United States.
Matthew RossDepartment of Chemistry, Northwestern University , Evanston, Illinois 60208, United States.
Pierre Moënne-LoccozDivision of Environmental & Biomolecular Systems, Institute of Environmental Health, Oregon Health & Science University , Portland, Oregon 97239, United States.
Yong ZhangDepartment of Biomedical Engineering, Chemistry, and Biological Sciences, Stevens Institute of Technology , Hoboken, New Jersey 07030, United States.ORCID 0000-0001-7207-6416
Oregon Health & Science University · USStevens Institute of Technology · USNorthwestern University · USUniversity of California, San Francisco · USUniversity of Mississippi · US

Funding

Training Program in Chemistry-Interface with BiologyT32GM070421 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI HERGENROTHER, PAUL · 2005 to 2019
$5.4M
DESIGNING HETERONUCLEAR METALLOENZYMESR01GM062211 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI LU, YI · 2001 to 2021
$5.1M
INSTITUTIONAL NRSA IN MOLECULAR BIOPHYSICST32GM008276 · NIGMS · UNIVERSITY OF ILLINOIS URBANA-CHAMPAIGN · PI GROSMAN, CLAUDIO F · 1988 to 2013
$4.8M
Nitric Oxide Reactions in MetalloenzymesR01GM074785 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MOENNE-LOCCOZ, PIERRE · 2006 to 2019
$3.8M
NIGMS NIH HHS R01 GM062211NIGMS NIH HHS R01 GM074785NIGMS NIH HHS T32 GM008276NIGMS NIH HHS T32 GM070421
6 · The paper itself

Abstract

The presence of a nonheme metal, such as copper and iron, in the heme-copper oxidase (HCO) superfamily is critical to the enzymatic activity of reducing O

Indexed as

Models, MolecularBinding SitesCobaltCrystallizationCrystallography, X-RayHemeManganeseOxidation-ReductionOxidoreductasesX-Ray Absorption SpectroscopyCobaltcopper oxidaseHemeManganeseOxidoreductases

Identifiers

PMID28768416
PMCPMC5673108
OpenAlexW2740081701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.