ReviewCurrent opinion in clinical nutrition and metabolic care2017
Measurement of metabolic fluxes using stable isotope tracers in whole animals and human patients.
Review in Current opinion in clinical nutrition and metabolic care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- A simple, anesthesia-free infusion technique for in vivo metabolic tracing.Science advances · 2026Article
- The Glutamate-Glutamine Axis in Pediatric Septic Shock: Immunometabolic Mechanisms, Biomarker Potential, and Clinical Implications.International journal of molecular sciences · 2026Review
- Stable Isotopes for the Study of Energy Nutrient Metabolic Pathways in Relation to Health and Disease.Metabolites · 2026Review
- Targeting Lung Cancer Metabolism: Therapeutic Opportunities and Challenges.Advances in experimental medicine and biology · 2026Review
- Urinary metabolome dynamics inMetabolomics : Official journal of the Metabolomic Society · 2025Article
- A simple, anesthesia-free infusion technique forbioRxiv : the preprint server for biology · 2025Article
- Targeted Metabolomic Methods forJournal of proteome research · 2025Article
- Paving the way for improved action: how nuclear techniques can advance the assessment of malnutrition.The American journal of clinical nutrition · 2025Article
- Mitochondrial Metabolomics in Cancer: Mass Spectrometry-Based Approaches for Metabolic Rewiring Analysis and Therapeutic Discovery.Metabolites · 2025Review
- Rejuvenation of the reconstitution potential and reversal of myeloid bias of aged HSCs upon pH treatment.Aging cell · 2024Article
- Regulatory mechanisms of one-carbon metabolism enzymes.The Journal of biological chemistry · 2023Review
- pH regulates hematopoietic stem cell potential via polyamines.EMBO reports · 2023Article
- LC-MS-Based Targeted Metabolomics for FACS-Purified Rare Cells.Analytical chemistry · 2023Article
- Alterations of Central Liver Metabolism of Pediatric Patients with Non-Alcoholic Fatty Liver Disease.International journal of molecular sciences · 2022Article
- Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism.iScience · 2022Article
- Stable Isotope Tracing and Metabolomics to Study In Vivo Brown Adipose Tissue Metabolic Fluxes.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Deciphering Metabolic Adaptability of Leukemic Stem Cells.Frontiers in oncology · 2022Review
- New Opportunities to Advance the Field of Sports Nutrition.Frontiers in sports and active living · 2022Review
- Cardiac Metabolism and Contractile Function in Mice with Reduced Trans-Endothelial Fatty Acid Transport.Metabolites · 2021Review
- Maneb alters central carbon metabolism and thiol redox status in a toxicant model of Parkinson's disease.Free radical biology & medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewMetabolic flux analysis using stable isotope labeled substrates allows for the tracing of carbon, nitrogen, and hydrogen atoms through metabolic pathways and is an invaluable tool for investigating dynamic metabolic changes occurring in health and disease. Studies of flux analysis in vivo are more technically challenging than in vitro or ex vivo but provide a highly detailed view of organ and/or systemic metabolism. We review here recent efforts in studies of diet and nutrition, non-small cell lung cancer, ischemia/reperfusion injury, and hemorrhagic shock where in vivo flux analysis was utilized to analyze metabolic modulation. RECENT
findingsRecent technical strides in the field of metabolomics afford sensitive and quantitative in vivo measurements of metabolic fluxes. Stable isotope tracing with C-glucose, C, N-glutamine, C-propionate, and other substrates are used in combination or in parallel to investigate the interplays among central carbon metabolic pathways and many other areas of the metabolome. SUMMARY: Stable isotope tracing in vivo provides opportunities to investigate physiological processes in the context of the whole animal. These approaches, often NMR spectroscopy or mass spectrometry (MS)-based, are growing in use and will likely find key applications in studying systemic disease, sports physiology, cancer metabolism, and personalized medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.