ArticleNeonatology2017
NICU Human Milk Dose and 20-Month Neurodevelopmental Outcome in Very Low Birth Weight Infants.
Article in Neonatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04540575 (Reducing Disparity in Receipt of Mother's Own Milk in Very Low Birth Weight Infants), which is not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reducing Disparity in Receipt of Mother's Own Milk in Very Low Birth Weight Infants: An Economic Intervention to Improve Adherence to Sustained Maternal Breast Pump Use
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Socioeconomic disparities in the postnatal growth of preterm infants: a systematic review.Pediatric research · 2025Pooled it
- A systematic review and meta-analysis of breastfeeding and neurodevelopmental outcomes in preterm infant.Frontiers in public health · 2024Pooled it
- Mother's Own Milk and Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2019Pooled it
- [Post-discharge fortified human milk feeding in preterm infants with moderate-to-high nutritional risk: a retrospective cohort study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Article
- Timing and intensity of lactation support influences NICU discharge on maternal milk.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- WHO exclusive breastfeeding recommendation and cognitive development in Germany.Scientific reports · 2026Article
- Parental involvement in zero-separation care: experiences and needs of parents of late preterm infants.Frontiers in pediatrics · 2026Article
- Article
- Strategies to support language development in neonatal intensive care unit: a narrative review.Clinical and experimental pediatrics · 2024Article
- Where does the time go? Temporal patterns of pumping behaviors in mothers of very preterm infants vary by sociodemographic and clinical factors.Frontiers in nutrition · 2024Article
- Importance of human milk for infants in the clinical setting: Updates and mechanistic links.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2023Review
- Dilemmas in establishing preterm enteral feeding: where do we start and how fast do we go?Journal of perinatology : official journal of the California Perinatal Association · 2023Review
- Article
- Regulation of Gut Microbiota through Breast Milk Feeding Benefits Language and Cognitive Development of Preterm Toddlers.Microorganisms · 2023Article
- Building better barriers: how nutrition and undernutrition impact pediatric intestinal health.Frontiers in immunology · 2023Review
- Neurodevelopmental outcomes of extremely preterm infants fed an exclusive human milk-based diet versus a mixed human milk + bovine milk-based diet: a multi-center study.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Cost Savings of Mother's Own Milk for Very Low Birth Weight Infants in the Neonatal Intensive Care Unit.PharmacoEconomics - open · 2022Article
- Proactive Lactation Care is Associated With Improved Outcomes in a Referral NICU.Journal of human lactation : official journal of International Lactation Consultant Association · 2022Article
- Article
- The impact of breast milk feeding on early brain development in preterm infants in China: An observational study.PloS one · 2022Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe association between human milk (HM) feeding in the NICU and neurodevelopmental (ND) outcome in very low birth weight (VLBW) infants is unclear. Limitations of previous studies include a lack of exact estimates of HM dose and of generalizability to minority populations.
objectiveTo determine the impact on ND outcome of an exact dose of HM received in the NICU in a diverse, contemporary cohort of VLBW infants.
methodsWe included 430 VLBW infants born in the period 2008-2012 for whom the mean daily dose (DD) of HM received during the stay in the NICU (NICU HM-DD) was calculated prospectively from the daily nutritional intake from admission to discharge. Outcomes included Bayley-III index scores at 20 months' corrected age (CA) as assessed upon ND follow-up, which were collected retrospectively. Multivariable linear regression analyses controlled for neonatal and social risk factors.
resultsEach 10 mL/kg/day increase in NICU HM-DD was associated with a 0.35 increase in cognitive index score (95% CI [0.03-0.66], p = 0.03), but no significant associations were detected for the language or motor indices.
conclusionsThere is a significant dose-dependent association between NICU HM intake and cognitive scores at 20 months' CA. Further follow-up will determine whether these findings persist at school age, and could help alleviate the special-education and health-care burden in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.