Evidence map›Paper›PMID 28768198›Full record

ArticleCell reports2017

Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury.

Véronique Lisi, Bhagat Singh, Michel Giroux, Elmer Guzman, Michio W Painter, Yung-Chih Cheng, Eric Huebner, Giovanni Coppola, Michael Costigan, Clifford J Woolf and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
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  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Mechanisms of neurite repair.Current opinion in neurobiology · 2020
    Review
  11. Abundant Neural circRNA Cdr1as Is Not Indispensable for Retina Maintenance.Frontiers in cell and developmental biology · 2020
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Intrinsic mechanisms of neuronal axon regeneration.Nature reviews. Neuroscience · 2018
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Véronique LisiDepartment of Molecular, Cellular, and Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Bhagat SinghF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Michel GirouxDepartment of Molecular, Cellular, and Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Elmer GuzmanDepartment of Molecular, Cellular, and Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA.
Michio W PainterF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Yung-Chih ChengF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Eric HuebnerF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Giovanni CoppolaDepartments of Psychiatry and Neurology, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Michael CostiganF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA; Anaesthesia Department, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Clifford J WoolfF.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Kenneth S KosikDepartment of Molecular, Cellular, and Developmental Biology, Neuroscience Research Institute, University of California, Santa Barbara, Santa Barbara, CA 93106, USA. Electronic address: kenneth.kosik@lifesci.ucsb.edu.
Boston Children's Hospital · USUniversity of California, Santa Barbara · USHarvard University · USUniversity of California, Los Angeles · US

Funding

SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI CHEN, CHINFEI · 2016 to 2020
$5.2M
The mechanisms of action of T-lymphocytes in neuropathic painR01NS074430 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI COSTIGAN, MICHAEL · 2012 to 2016
$2.0M
Spectral Laser Scanning Biological MicroscopeS10OD010610 · OD · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI RAVEN, MARY A · 2012 to 2012
$429k
CIHR DC0190SRCIHR MFE-146723NICHD NIH HHS P30 HD018655NICHD NIH HHS U54 HD090255NIH HHS S10 OD010610NINDS NIH HHS R01 NS074430
6 · The paper itself

Abstract

Peripheral nerve regeneration after injury requires a broad program of transcriptional changes. We investigated the basis for the enhanced nerve regenerative capacity of the CAST/Ei mouse strain relative to C57BL/6 mice. RNA sequencing of dorsal root ganglia (DRG) showed a CAST/Ei-specific upregulation of Ascl1 after injury. Ascl1 overexpression in DRG neurons of C57BL/6 mice enhanced their neurite outgrowth. Ascl1 is regulated by miR-7048-3p, which is downregulated in CAST/Ei mice. Inhibition of miR-7048-3p enhances neurite outgrowth. Following injury, CAST/Ei neurons largely retained their mature neuronal profile as determined by single-cell RNA- seq, whereas the C57BL/6 neurons acquired an immature profile. These findings suggest that one facet of the enhanced regenerative phenotype is preservation of neuronal identity in response to injury.

Indexed as

Nerve RegenerationAnimalsBasic Helix-Loop-Helix ProteinsMaleMiceMicroRNAsNeuritesPeripheral Nerve InjuriesAscl1 protein, mouseBasic Helix-Loop-Helix ProteinsMicroRNAsAscl1CAST/Eidorsal root gangliamiR-7048regenerationRNA sequencingsingle-cell analyses

Identifiers

PMID28768198
PMCPMC5565222
OpenAlexW2727920467

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.