Evidence map›Paper›PMID 28768196›Full record

ArticleCell reports2017

A Cooperative Mechanism Involving Ca

Peter Koppensteiner, Riccardo Melani, Ipe Ninan

Abstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Asymmetrical modulation of fear expression via GABAProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. GABAIBRO neuroscience reports · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Mechanisms and Regulation of Neuronal GABACurrent topics in behavioral neurosciences · 2022
    Review
  11. Review
  12. Article
  13. Article
  14. GABAeLife · 2021
    Article
  15. Article
  16. The organizing principle of GABABasic & clinical pharmacology & toxicology · 2020
    Review
  17. Article
  18. Article
  19. Frontiers in pharmacology · 2019
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Peter KoppensteinerDepartment of Psychiatry, NYU Neuroscience Institute, NYU Langone Medical Center, New York, NY 10016, USA.
Riccardo MelaniDepartment of Psychiatry, NYU Neuroscience Institute, NYU Langone Medical Center, New York, NY 10016, USA.
Ipe NinanDepartment of Psychiatry, NYU Neuroscience Institute, NYU Langone Medical Center, New York, NY 10016, USA. Electronic address: ipe.ninan@nyumc.org.

Funding

Mechanisms of developmental regulation of affective behaviorsR01HD076914 · NICHD · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI NINAN, IPE · 2014 to 2019
$1.8M
NICHD NIH HHS R01 HD076914
6 · The paper itself

Abstract

The medial habenula-interpeduncular nucleus (MHb-IPN) pathway, which connects the limbic forebrain to the midbrain, has recently been implicated in aversive behaviors. The MHb-IPN circuit is characterized by a unique topographical organization, an excitatory role of GABA, and a prominent co-release of neurotransmitters and neuropeptides. However, little is known about synaptic plasticity in this pathway. An application of a high-frequency stimulation resulted in a long-lasting potentiation of glutamate release in IPN neurons. Our experiments reveal that a Ca

Indexed as

AnimalsInterpeduncular NucleusMiceMice, TransgenicNeuronal PlasticityReceptors, AMPAReceptors, GABA-BSynapsesReceptors, AMPAReceptors, GABA-Badolescencecalcium-permeable AMPA receptorsfear extinctionGABAGABABglutamateinterpeduncular nucleusmedial habenularetrograde GABA releasesynaptic plasticity

Identifiers

PMID28768196
PMCPMC5568868

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.