ArticleCell reports2017
Attenuation of Synaptic Potentials in Dendritic Spines.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Editorial: Optical interrogation of the nervous system: recent advances in optical techniques and their applications.Frontiers in neuroscience · 2026Article
- An anatomical substrate of credit assignment in reinforcement learning.bioRxiv : the preprint server for biology · 2025Article
- Ultrafast optical imaging techniques for exploring rapid neuronal dynamics.Neurophotonics · 2025Review
- Contribution of individual excitatory synapses on dendritic spines to electrical signaling.Frontiers in neuroscience · 2025Article
- ClScience advances · 2024Article
- Optical Estimation of Membrane Potential Values Using Fluorescence Lifetime Imaging Microscopy and Hybrid Chemical-Genetic Voltage Indicators.Bioelectricity · 2024Article
- Ion-concentration gradients induced by synaptic input increase the voltage depolarization in dendritic spines.Journal of computational neuroscience · 2024Article
- Clinical parameters affect the structure and function of superficial pyramidal neurons in the adult human neocortex.Brain communications · 2024Article
- Electrical properties of dendritic spines.Biophysical journal · 2023Review
- A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics.eLife · 2023Article
- Diversity of dynamic voltage patterns in neuronal dendrites revealed by nanopipette electrophysiology.Nanoscale · 2023Article
- Differential effects of group III metabotropic glutamate receptors on spontaneous inhibitory synaptic currents in spine-innervating double bouquet and parvalbumin-expressing dendrite-targeting GABAergic interneurons in human neocortex.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Genetically encoded fluorescent sensors for imaging neuronal dynamics in vivo.Journal of neurochemistry · 2023Review
- Electrophysiology of Dendritic Spines: Information Processing, Dynamic Compartmentalization, and Synaptic Plasticity.Advances in neurobiology · 2023Article
- Dendritic Morphology Affects the Velocity and Amplitude of Back-propagating Action Potentials.Neuroscience bulletin · 2022Article
- A trafficking motif alters GEVI activity implicating persistent protein interactions at the membrane.Biophysical reports · 2022Article
- Voltage compartmentalization in dendritic spines in vivo.Science (New York, N.Y.) · 2022Article
- Bringing Anatomical Information into Neuronal Network Models.Advances in experimental medicine and biology · 2022Article
- Simultaneous two-photon imaging of action potentials and subthreshold inputs in vivo.Nature communications · 2021Article
- The glutamatergic synapse: a complex machinery for information processing.Cognitive neurodynamics · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Dendritic spines receive the majority of excitatory inputs in many mammalian neurons, but their biophysical properties and exact role in dendritic integration are still unclear. Here, we study spine electrical properties in cultured hippocampal neurons using an improved genetically encoded voltage indicator (ArcLight) and two-photon glutamate uncaging. We find that back-propagating action potentials (bAPs) fully invade dendritic spines. However, uncaging excitatory post-synaptic potentials (uEPSPs) generated by glutamate photorelease, ranging from 4 to 27 mV in amplitude, are attenuated by up to 4-fold as they propagate to the parent dendrites. Finally, the simultaneous occurrence of bAPs and uEPSPs results in sublinear summation of membrane potential. Our results demonstrate that spines can behave as electric compartments, reducing the synaptic inputs injected into the cell, while receiving bAPs are unmodified. The attenuation of EPSPs by spines could have important repercussions for synaptic plasticity and dendritic integration.
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