ArticleCell metabolism2017
Loss of Brain Aerobic Glycolysis in Normal Human Aging.
Article in Cell metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
188 citing papers in PubMed, 2 syntheses or guidelines pooled it, 312 citations in OpenAlex.
- Spatial Dissociation of Atrophy and Hypophysiology in Alzheimer's Disease: Implications for Biomarkers.Human brain mapping · 2025Pooled it
- The Effects of Benzodiazepine Use and Abuse on Cognition in the Elders: A Systematic Review and Meta-Analysis of Comparative Studies.Frontiers in psychiatry · 2020Pooled it
- Carnosine supplementation improves cognitive outcomes in younger participants of the NEAT trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Trial
- An fMRI Investigation into the Effects of Ketogenic Medium-Chain Triglycerides on Cognitive Function in Elderly Adults: A Pilot Study.Nutrients · 2021Trial
- Functional energetic responses and individual variance of the human brain revealed by quantitative imaging of adenosine triphosphate production rates.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2018Trial
- RNA G-quadruplex-protein interactions: from nuclear RNA processing to cytoplasmic stress response and neurodegeneration.RNA biology · 2026Review
- Atlas of Brain Glucose Metabolism Using Deuterium Metabolic Imaging at 3 T.Magnetic resonance in medicine · 2026Article
- Individual-level metabolic connectivity captures cortical morphology and their coupling strengthens in the ageing brain.European journal of nuclear medicine and molecular imaging · 2026Article
- A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026Review
- The organellar biology of aging: A mitochondrial vantage.Molecular biology reports · 2026Review
- Baseline electrophysiology versus oxidative metabolism as traits of inter-network differences in neurometabolic association.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Psychological stress induced mitochondrial response in humans and its medial prefrontal biomarker correlates.Translational psychiatry · 2026Article
- ATP-depleting spreading depolarizations preferentially originate in the somatosensory cortex during in situ energy deprivation.npj metabolic health and disease · 2026Article
- Age dependence of brain oxygen metabolism in adults assessed by 3D constrained quantitative BOLD MRI.NeuroImage · 2026Article
- Aerobic glycolysis in Schizophrenia: Developmental rescue or energetic breakdown?Molecular psychiatry · 2026Review
- Modeling human neurodegenerative disorders in Drosophila: strategies and translational opportunities.Molecular biology reports · 2026Review
- High-intensity interval and moderate-intensity continuous training on cerebral energy metabolism in older rats.GeroScience · 2026Article
- Vascular and Neural Transcriptomics Reveal Stage-Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension.Journal of the American Heart Association · 2026Article
- Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Individual-level metabolic connectivity captures cortical morphology and their coupling strengthens with age.bioRxiv : the preprint server for biology · 2026Article
128 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The normal aging human brain experiences global decreases in metabolism, but whether this affects the topography of brain metabolism is unknown. Here we describe PET-based measurements of brain glucose uptake, oxygen utilization, and blood flow in cognitively normal adults from 20 to 82 years of age. Age-related decreases in brain glucose uptake exceed that of oxygen use, resulting in loss of brain aerobic glycolysis (AG). Whereas the topographies of total brain glucose uptake, oxygen utilization, and blood flow remain largely stable with age, brain AG topography changes significantly. Brain regions with high AG in young adults show the greatest change, as do regions with prolonged developmental transcriptional features (i.e., neoteny). The normal aging human brain thus undergoes characteristic metabolic changes, largely driven by global loss and topographic changes in brain AG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.