Evidence map›Paper›PMID 28768171›Full record

ReviewCell metabolism2017

The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.

Rachel L Wolfson, David M Sabatini

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04784806 (Amino Acid Profile and Muscle Protein Synthetic Response to Consuming Meat or Plant-based Alternatives), which is not on this map. Cited by 327 papers.

0numbers the graph read from it
0cells of the map it votes in
327citing papers in PubMed
26.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04784806 nacompletednot on this mapstarted 2021, after this paper: background citation

Amino Acid Profile and Muscle Protein Synthetic Response to Consuming Meat or Plant-based Alternatives

TypeinterventionalSponsorUniversity of California, DavisRan2021 to 2021Enrolled17ConditionsHealthyArmsGround beef, Ground pork, Tofu, Beyond Meat
3 · Its place in the literature

Who cites it

327 citing papers in PubMed, 546 citations in OpenAlex.

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267 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rachel L WolfsonWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
David M SabatiniWhitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research at MIT, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; Broad Institute, 415 Main Street, Cambridge, MA 02142, USA. Electronic address: sabatini@wi.mit.edu.
Broad Institute · US

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Regulation of the mTOR Pathway By NutrientsR01CA103866 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2004 to 2021
$7.0M
TRANSLATIONAL CONTROL BY RAPAMYCIN-SENSITIVE SIGNALINGR01AI047389 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2000 to 2021
$4.9M
Novel Components of the mTORC1 and mTORC2 PathwaysR37AI047389 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI SABATINI, DAVID M. · 2010 to 2019
$4.8M
Characterization of GATOR1 signaling to mTORC1 and its role in cancerF30CA189333 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WOLFSON, RACHEL LAURA · 2015 to 2017
$146k
NCI NIH HHS F30 CA189333NCI NIH HHS R01 CA103866NIAID NIH HHS R01 AI047389NIAID NIH HHS R37 AI047389NIGMS NIH HHS T32 GM007753
6 · The paper itself

Abstract

The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental inputs, including amino acids. Over the past 10 years, a number of proteins have been identified that help transmit amino acid availability to mTORC1. However, amino acid sensors for this pathway have only recently been discovered. Here, we review these recent advances and highlight the variety of unexplored questions that emerge from the identification of these sensors.

Indexed as

Amino AcidsAnimalsHumansMechanistic Target of Rapamycin Complex 1Amino AcidsMechanistic Target of Rapamycin Complex 1amino acid sensingamino acid sensorsCASTORgrowth controlmTORmTORC1nutrient sensingSestrin2SestrinsSLC38A9

Identifiers

PMID28768171
PMCPMC5560103
OpenAlexW2739510344

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.