Evidence map›Paper›PMID 28767983›Full record

ArticleMemorias do Instituto Oswaldo Cruz2017

Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids.

Jeziel D Damasceno, Gabriel LA Silva, Christian Tschudi, Luiz Ro Tosi

Abstract read
In one paragraph

Article in Memorias do Instituto Oswaldo Cruz, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Regulation of Antigenic Variation byPathogens (Basel, Switzerland) · 2021
    Review
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jeziel D DamascenoUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Ribeirão Preto, SP, Brasil.
Gabriel LA SilvaUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Ribeirão Preto, SP, Brasil.
Christian TschudiYale UniversitySchool of Public Health, Department of Epidemiology of Microbial Diseases, New Haven, CT, USA.
Luiz Ro TosiUniversidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Ribeirão Preto, SP, Brasil.

Funding

TRANSCRIPTION AND RNA PROCESSING IN TRYPANOSOMESR01AI028798 · NIAID · YALE UNIVERSITY · PI TSCHUDI, CHRISTIAN · 1990 to 2020
$10.9M
Mechanism of Infectivity Acquisition in African TrypanosomesR01AI110325 · NIAID · YALE UNIVERSITY · PI TSCHUDI, CHRISTIAN · 2014 to 2023
$4.4M
RNA METABOLISM IN TRYPANOSOMESR37AI028798 · NIAID · YALE UNIVERSITY · PI ULLU, ELISABETTA · 2010 to 2013
$2.9M
NIAID NIH HHS R01 AI028798NIAID NIH HHS R01 AI110325NIAID NIH HHS R37 AI028798
6 · The paper itself

Abstract

The Telomeric Repeat-containing RNAs (TERRA) participate in the homeostasis of telomeres in higher eukaryotes. Here, we investigated the expression of TERRA in Leishmania spp. and Trypanosoma brucei and found evidences for its expression as a specific RNA class. The trypanosomatid TERRA are heterogeneous in size and partially polyadenylated. The levels of TERRA transcripts appear to be modulated through the life cycle in both trypanosomatids investigated, suggesting that TERRA play a stage-specific role in the life cycle of these early-branching eukaryotes.

Indexed as

LeishmaniaRepetitive Sequences, Nucleic AcidRNATelomeraseTrypanosoma brucei bruceiRNATelomerase

Identifiers

PMID28767983
PMCPMC5530550

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.