ArticlePloS one2017
Bruch´s membrane thickness in relationship to axial length.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- VEGFA may be a potential marker of myopic choroidal thickness and vascular density changes.Scientific reports · 2024Article
- Heterogenous thinning of peripapillary tissues occurs early during high myopia development in juvenile tree shrews.Experimental eye research · 2024Article
- Retardation of myopia by atropine regimes.International journal of ophthalmology · 2024Review
- Myopic Versus Glaucomatous Parapapillary Beta Zone in Myopic Eyes Versus Eyes With Secondary Angle-Closure Glaucoma.Investigative ophthalmology & visual science · 2023Article
- IMI-Nonpathological Human Ocular Tissue Changes With Axial Myopia.Investigative ophthalmology & visual science · 2023Article
- Longitudinal Changes of Bruch's Membrane Opening, Anterior Scleral Canal Opening, and Border Tissue in Experimental Juvenile High Myopia.Investigative ophthalmology & visual science · 2023Article
- Anatomic Peculiarities Associated with Axial Elongation of the Myopic Eye.Journal of clinical medicine · 2023Review
- Photoreceptor density in relation to axial length and retinal location in human eyes.Scientific reports · 2022Article
- Epiregulin, epigen and betacellulin antibodies and axial elongation in young guinea pigs with lens-induced myopization.BMC ophthalmology · 2022Article
- Dome-Shaped Macula versus Ridge-Shaped Macula Eyes in High Myopia Based on the 12-line Radial Optical Coherence Tomography Scan Pattern. Differences in Clinical Features.Diagnostics (Basel, Switzerland) · 2021Article
- Anomalous Angiogenesis in Retina.Biomedicines · 2021Article
- Location of Parapapillary Gamma Zone and Vertical Fovea Location. The Beijing Eye Study 2011.Investigative ophthalmology & visual science · 2021Article
- Review on current concepts of myopia and its control strategies.International journal of ophthalmology · 2021Review
- Posterior pole retinal thickness distribution pattern in keratoconus.International ophthalmology · 2020Article
- Advances in myopia research anatomical findings in highly myopic eyes.Eye and vision (London, England) · 2020Review
- Bruch's membrane opening enlargement and its implication on the myopic optic nerve head.Scientific reports · 2019Article
- Relationship between ocular biometry and severity of primary angle-closure glaucoma: relevance for predictive, preventive, and personalized medicine.The EPMA journal · 2019Article
- [Epidemiology and anatomy of myopia].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2019Review
- Bruch's Membrane Thickness and Retinal Pigment Epithelium Cell Density in Experimental Axial Elongation.Scientific reports · 2019Article
- IMI - Report on Experimental Models of Emmetropization and Myopia.Investigative ophthalmology & visual science · 2019Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo assess a potential role of Bruch´s membrane (BM) in the biomechanics of the eye, we measured its thickness and the density of retinal pigment epithelium (RPE) cells in various ocular regions in eyes of varying axial length.
methodsHuman globes, enucleated because of an ocular tumor or end-stage glaucoma were prepared for histological examination. Using light microscopy, the histological slides were histomorphometrically examined applying a digitized image analysis system.
resultsThe study included 104 eyes with a mean axial length of 27.9±3.2 mm (range:22.6mm-36.5mm). In eyes without congenital glaucoma, BM was significantly thickest (P<0.001) at the ora serrata, followed by the posterior pole, the midpoint between equator and posterior pole (MBEPP), and finally the equator. BM thickness was not significantly correlated with axial length (ora serrata: P = 0.93; equator:P = 0.31; MBEPP:P = 0.15; posterior pole:P = 0.35). RPE cell density in the pre-equatorial region (P = 0.02; regression coefficient r = -0.24) and in the retro-equatorial region (P = 0.03; r = -0.22) decreased with longer axial length, while RPE cell density at the ora serrata (P = 0.35), the MBEPP (P = 0.06; r = -0.19) and the posterior pole (P = 0.38) was not significantly correlated with axial length. Highly myopic eyes with congenital glaucoma showed a tendency towards lower BM thickness and lower RPE cell density at all locations.
conclusionsBM thickness, in contrast to scleral and choroidal thickness, was independent of axial length in eyes without congenital glaucoma. In association with an axial elongation associated decrease in the RPE cell density in the midperiphery, the findings support the notion of a biomechanical role BM may play in the process of emmetropization/myopization.
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