ArticlePloS one2017
Impact of stress, fear and anxiety on the nociceptive responses of larval zebrafish.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 97 citations in OpenAlex.
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- Pain management in zebrafish : Report from a FELASA Working Group.Laboratory animals · 2024Review
- Pain, Fear, Anxiety, and Stress: Relations to the Endogenous Opioid System.Advances in neurobiology · 2024Article
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- Environmental enrichment decreases anxiety-like behavior in zebrafish larvae.Developmental psychobiology · 2022Article
- Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration.Nature communications · 2021Article
- The Necessity of Methodological Advances in Pain Research: Challenges and Opportunities.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- About Welfare and Stress in the Early Stages of Fish.Frontiers in veterinary science · 2021Article
- The Effects of Early Life Stress on the Brain and Behaviour: Insights From Zebrafish Models.Frontiers in cell and developmental biology · 2021Review
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- Acute and chronic stress prevents responses to pain in zebrafish: evidence for stress-induced analgesia.The Journal of experimental biology · 2020Article
- Combined effects of temperature increase and immune challenge in two wild gudgeon populations.Fish physiology and biochemistry · 2020Article
- Quantification of the influence of drugs on zebrafish larvae swimming kinematics and energetics.PeerJ · 2020Article
- Ethical and IACUC Considerations Regarding Analgesia and Pain Management in Laboratory Rodents.Comparative medicine · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Both adult and larval zebrafish have been demonstrated to show behavioural responses to noxious stimulation but also to potentially stress- and fear or anxiety- eliciting situations. The pain or nociceptive response can be altered and modulated by these situations in adult fish through a mechanism called stress-induced analgesia. However, this phenomenon has not been described in larval fish yet. Therefore, this study explores the behavioural changes in larval zebrafish after noxious stimulation and exposure to challenges that can trigger a stress, fear or anxiety reaction. Five-day post fertilization zebrafish were exposed to either a stressor (air emersion), a predatory fear cue (alarm substance) or an anxiogenic (caffeine) alone or prior to immersion in acetic acid 0.1%. Pre- and post-stimulation behaviour (swimming velocity and time spent active) was recorded using a novel tracking software in 25 fish at once. Results show that larvae reduced both velocity and activity after exposure to the air emersion and alarm substance challenges and that these changes were attenuated using etomidate and diazepam, respectively. Exposure to acetic acid decreased velocity and activity as well, whereas air emersion and alarm substance inhibited these responses, showing no differences between pre- and post-stimulation. Therefore, we hypothesize that an antinociceptive mechanism, activated by stress and/or fear, occur in 5dpf zebrafish, which could have prevented the larvae to display the characteristic responses to pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.