ArticleMedicine2017
Carotid intima-media thickness is a novel predictor of new onset of hypertension in normotensive subjects.
Article in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Close relationship between electrocardiogram QRS duration and the risk of developing hypertension.Journal of human hypertension · 2025Article
- Clinical Significance of Altered Vascular Morphology and Function in Normotension.Current hypertension reports · 2023Review
- Increased Impact of Serum Uric Acid on Arterial Stiffness and Atherosclerosis in Females.Journal of atherosclerosis and thrombosis · 2022Article
- Association of blood pressure and hypertension with radiographic damage among the patients with ankyloing spondylitis.Medicine · 2022Article
- Level of advanced oxidation protein products is associated with subclinical atherosclerosis.BMC cardiovascular disorders · 2022Article
- Are Any Changes in Carotid Intima-Media Thickness Associated with Cardiometabolic Risk Among Adult Bantu Central African Hypertensive Patients from Monkole and Biamba Marie Mutombo Hospitals?Vascular health and risk management · 2022Article
- Examination of Large Artery Atherosclerosis could Reveal Small Artery Retinopathy in Untreated Middle-Aged Individuals.Journal of atherosclerosis and thrombosis · 2022Article
- Central blood pressure predicts the development of hypertension in the general population.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Observational
- Vascular, cardiac and renal target organ damage associated to arterial hypertension: which noninvasive tools for detection?Journal of human hypertension · 2020Review
- Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers.Journal of atherosclerosis and thrombosis · 2020Article
- Impacts of lifestyle behavior and shift work on visceral fat accumulation and the presence of atherosclerosis in middle-aged male workers.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased carotid intima-media thickness (IMT) in individuals without hypertension might indicate other factors promoting the atherosclerotic process that are often simultaneously clustered in individuals. The present study tested the hypothesis that carotid IMT predicts new onset of hypertension in the normotensive subjects.A total of 867 participants were enrolled from our yearly physical checkup program and their carotid IMT was measured. After a baseline examination, the subjects were followed up for a median of 1091 days with the endpoint being the development of hypertension.At baseline, the carotid IMT value was 0.75 ± 0.16 mm. Hypertension developed in 184 subjects during the follow-up (76.9/1000 person-years). The incidence of hypertension was increased across the tertiles of the carotid IMT value (39.6, 70.0, and 134.5/1000 person-years in the first, second, and third tertiles, respectively, P < .001 by log-rank test). Multivariate Cox-hazard analysis after adjustment identified carotid IMT, taken as a continuous variable, as a significant predictor of new-onset hypertension (hazard ratio = 7.08, 95% confidence interval = 3.06-15.39). Furthermore, multivariate linear regression analyses indicated a significant correlation between the carotid IMT at baseline and yearly increases in systolic blood pressure during the follow-up period (β = 0.189, P < .001).Carotid IMT is an independent predictor of hypertension onset in normotensive subjects. The findings also suggested a close association between increased carotid IMT and blood pressure.
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