ArticleMedicine2017
Association between hemorrhoid and risk of coronary heart disease: A nationwide population-based cohort study.
Article in Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- The association of hemorrhoids with the incidence of heart failure: a nationwide cohort study.Annals of translational medicine · 2025Article
- Hemorrhoidal Disease in the Diabetic Population: The Effects of Glucose Regulation and Lipid Profile.Life (Basel, Switzerland) · 2025Article
- Association of hemorrhoidal disease with dementia risk: a nationwide cohort study.Frontiers in neurology · 2025Article
- Hemorrhoids and cardiovascular disease: A bidirectional Mendelian randomization study.Open medicine (Warsaw, Poland) · 2025Article
- Article
- Hemorrhoidal disease and chronic venous insufficiency: Concomitance or coincidence; results of the CHORUS study (Chronic venous and HemORrhoidal diseases evalUation and Scientific research).Journal of gastroenterology and hepatology · 2020Article
- Association of Hemorrhoids With Hashimoto's Thyroiditis and Associated Comorbidities: A Nationwide Population-Based Cohort Study.Frontiers in endocrinology · 2020Article
- Association of Hemorrhoid Vascular Injuries with Cigarette Smoking-An Evaluation with Interesting Prospects.Surgery journal (New York, N.Y.) · 2019Article
- Article
- Association of bowel and tear suppression with coronary artery disease: A case control study.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of the study was to address the association between hemorrhoid and the subsequent risk of coronary heart disease (CHD) development.This retrospective cohort study used reimbursement claims data from the Longitudinal Health Insurance Database 2000 in Taiwan. Thirty-three thousand thirty-four patients with hemorrhoids and 132,136 age-, gender-, and index year matched controls between 2000 and 2010 were identified. Cox model was performed to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of CHD development for the hemorrhoid cohort compared with the nonhemorrhoid cohort.During a follow-up period of 12 years, the overall incidence rate of CHD was 9.91 per 1000 person-years in the hemorrhoid patients and was 1.36-fold higher than in the nonhemorrhoid cohort (7.28 per 1000 person-years) with an adjusted hazard ratio (aHR) of 1.27 (95% CI = 1.21-1.34). Moreover, compared with the nonhemorrhoid patients without these comorbidities, among patients with hemorrhoids, those with any 2 comorbidities were at a significantly increased risk of CHD (HR = 7.12, 95% CI = 6.61-7.67; P < .001), followed by those with any 1 comorbidity (HR = 3.23, 95% CI = 2.94-3.54; P < .001).We found that hemorrhoid patients had a 1.27-fold higher risk of CHD compared with those without hemorrhoids after adjusting for the potential confounding factors.
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