ArticleMedicine and science in sports and exercise2017
Bioenergetics and ATP Synthesis during Exercise: Role of Group III/IV Muscle Afferents.
Article in Medicine and science in sports and exercise, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Effects of Physical Exercise on Neuroplasticity and Brain Function: A Systematic Review in Human and Animal Studies.Neural plasticity · 2020Pooled it
- Shorter Set Configurations Attenuate Performance Loss and Lactatemia During Resistance Training in Postmenopausal Women: A Randomized Crossover Trial (CARE Project).Journal of strength and conditioning research · 2026Trial
- Delaying task failure in high-intensity exercise: a Pi-afferent-effort framework for targeted sports nutrition.Journal of the International Society of Sports Nutrition · 2026Review
- Finger tapping at maximal speed evokes crossover fatigability in the other hand.Frontiers in human neuroscience · 2026Article
- Rating of perceived exertion as an indirect indicator of velocity loss during power back squat exercise with moderate loads.Frontiers in sports and active living · 2026Article
- Lactic acidosis: implications for human exercise performance.European journal of applied physiology · 2025Review
- Perceived exertion reflects fatigue conditions during power-aimed resistance training.International journal of sports medicine · 2025Article
- Article
- Neuromuscular Fatigability Associated with Different Pacing Strategies During an Ultra-Endurance Pull-Up Task: A Case Study.International journal of exercise science · 2022Article
- Acute high-intensity exercise and skeletal muscle mitochondrial respiratory function: role of metabolic perturbation.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Bioenergetic Mechanisms Linking V˙O2 Kinetics and Exercise Tolerance.Exercise and sport sciences reviews · 2021Article
- A Modular Mathematical Model of Exercise-Induced Changes in Metabolism, Signaling, and Gene Expression in Human Skeletal Muscle.International journal of molecular sciences · 2021Article
- On the Influence of Group III/IV Muscle Afferent Feedback on Endurance Exercise Performance.Exercise and sport sciences reviews · 2020Review
- Bioenergetic basis for the increased fatigability with ageing.The Journal of physiology · 2019Article
- Contralateral fatigue during severe-intensity single-leg exercise: influence of acute acetaminophen ingestion.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Exercise tolerance through severe and extreme intensity domains.Physiological reports · 2019Article
- Response.Medicine and science in sports and exercise · 2018Article
- Influence of group III/IV muscle afferents on small muscle mass exercise performance: a bioenergetics perspective.The Journal of physiology · 2018Article
- Mechanomyographic responses for the biceps brachii are associated with failure times during isometric force tasks.Physiological reports · 2018Article
- Should We Trust Perceived Effort for Loading Control and Resistance Exercise Prescription After ACL Reconstruction?Sports healthArticle
Corrections and comments
- Commented on by
- Commented on byResponse.2018
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe purpose of this study was to investigate the role of the group III/IV muscle afferents in the bioenergetics of exercising skeletal muscle beyond constraining the magnitude of metabolic perturbation.
methodsEight healthy men performed intermittent isometric knee-extensor exercise to task failure at ~58% maximal voluntary contraction under control conditions (CTRL) and with lumbar intrathecal fentanyl to attenuate group III/IV leg muscle afferents (FENT). Intramuscular concentrations of phosphocreatine (PCr), inorganic phosphate (Pi), diprotonated phosphate (H2PO4), adenosine triphosphate (ATP), and pH were determined using phosphorous magnetic resonance spectroscopy (P-MRS).
resultsThe magnitude of metabolic perturbation was significantly greater in FENT compared with CTRL for [Pi] (37.8 ± 16.8 vs 28.6 ± 8.6 mM), [H2PO4] (24.3 ± 12.2 vs 17.9 ± 7.1 mM), and [ATP] (75.8% ± 17.5% vs 81.9% ± 15.8% of baseline), whereas there was no significant difference in [PCr] (4.5 ± 2.4 vs 4.4 ± 2.3 mM) or pH (6.51 ± 0.10 vs 6.54 ± 0.14). The rate of perturbation in [PCr], [Pi], [H2PO4], and pH was significantly faster in FENT compared with CTRL. Oxidative ATP synthesis was not significantly different between conditions. However, anaerobic ATP synthesis, through augmented creatine kinase and glycolysis reactions, was significantly greater in FENT than in CTRL, resulting in a significantly greater ATP cost of contraction (0.049 ± 0.016 vs 0.038 ± 0.010 mM·min·N).
conclusionGroup III/IV muscle afferents not only constrain the magnitude of perturbation in intramuscular Pi, H2PO4, and ATP during small muscle mass exercise but also seem to play a role in maintaining efficient skeletal muscle contractile function in men.
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