ArticleDevelopmental psychobiology2017
Phenotypic outcomes in adolescence and adulthood in the scarcity-adversity model of low nesting resources outside the home cage.
Article in Developmental psychobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Sex-Specific Outcomes in a Rat Model of Early-Life Stress Due to Adverse Caregiving.Neurotoxicity research · 2025Article
- Sex- and reward-dependent effects of early life scarcity-adversity on adolescent behavioral responses to natural rewards.Frontiers in behavioral neuroscience · 2025Article
- Gene Expression After Exercise Is Disrupted by Early-Life Stress.Developmental psychobiology · 2025Article
- Developmental alcohol exposure is exhausting: Sleep and the enduring consequences of alcohol exposure during development.Neuroscience and biobehavioral reviews · 2024Review
- Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress.Addiction neuroscience · 2023Article
- Neurodevelopmental origins of substance use disorders: Evidence from animal models of early-life adversity and addiction.The European journal of neuroscience · 2022Review
- Rodent models of early adversity: Impacts on developing social behavior circuitry and clinical implications.Frontiers in behavioral neuroscience · 2022Review
- Epigenetic Mechanism of 5-HT/NE/DA Triple Reuptake Inhibitor on Adult Depression Susceptibility in Early Stress Mice.Frontiers in pharmacology · 2022Article
- The Neurobiology of Infant Attachment-Trauma and Disruption of Parent-Infant Interactions.Frontiers in behavioral neuroscience · 2022Review
- Neonatal resource scarcity alters maternal care and impacts offspring core temperature and growth in rats.Developmental psychobiology · 2021Article
- The Developmental Origins of Opioid Use Disorder and Its Comorbidities.Frontiers in human neuroscience · 2021Review
- Elevated infant cortisol is necessary but not sufficient for transmission of environmental risk to infant social development: Cross-species evidence of mother-infant physiological social transmission.Development and psychopathology · 2020Article
- Article
- Early Life Trauma Has Lifelong Consequences for Sleep And Behavior.Scientific reports · 2019Article
- During infant maltreatment, stress targets hippocampus, but stress with mother present targets amygdala and social behavior.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Preventing epigenetic traces of caregiver maltreatment: A role for HDAC inhibition.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2019Article
- Female pups receive more maltreatment from stressed dams.Developmental psychobiology · 2019Article
- Pharmacological manipulation of DNA methylation normalizes maternal behavior, DNA methylation, and gene expression in dams with a history of maltreatment.Scientific reports · 2019Article
- Bundling the haystack to find the needle: Challenges and opportunities in modeling risk and resilience following early life stress.Frontiers in neuroendocrinology · 2019Review
- Neurobiology of maternal regulation of infant fear: the role of mesolimbic dopamine and its disruption by maltreatment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Early life adversity is known to disrupt behavioral trajectories and many rodent models have been developed to characterize these stress-induced outcomes. One example is the scarcity-adversity model of low nesting resources. This model employs resource scarcity (i.e., low nesting materials) to elicit adverse caregiving conditions (including maltreatment) toward rodent neonates. Our lab utilizes a version of this model wherein caregiving exposures occur outside the home cage during the first postnatal week. The aim of this study was to determine adolescent and adult phenotypic outcomes associated with this model, including assessment of depressive- and anxiety-like behaviors and performance in different cognitive domains. Exposure to adverse caregiving had no effect on adolescent behavioral performance whereas exposure significantly impaired adult behavioral performance. Further, adult behavioral assays revealed substantial differences between sexes. Overall, data demonstrate the ability of repeated exposure to brief bouts of maltreatment outside the home cage in infancy to impact the development of several behavioral domains later in life.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.