Evidence map›Paper›PMID 28767087›Full record

ArticleMolecules (Basel, Switzerland)2017

Novel Methylselenoesters as Antiproliferative Agents.

Nuria Díaz-Argelich, Ignacio Encío, Daniel Plano, Aristi P Fernandes, Juan Antonio Palop, Carmen Sanmartín

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Harnessing Methylselenol (CHAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Selenium Compounds as Novel Potential Anticancer Agents.International journal of molecular sciences · 2021
    Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nuria Díaz-ArgelichDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain. ndiaz@alumni.unav.es.
Ignacio EncíoDepartment of Health Sciences, Public University of Navarra, Avda. Barañain s/n, E-31008 Pamplona, Spain. dplano@unav.es.
Daniel PlanoDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain. jpalop@unav.es.
Aristi P FernandesDivision of Biochemistry, Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, SE-171 77 Stockholm, Sweden. Aristi.Fernandes@ki.se.
Juan Antonio PalopDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain. ignacio.encio@unavarra.es.
Carmen SanmartínDepartment of Organic and Pharmaceutical Chemistry, Faculty of Pharmacy and Nutrition, University of Navarra, Irunlarrea 1, E-31008 Pamplona, Spain. sanmartin@unav.es.
Navarre Institute of Health Research · ESKarolinska Institutet · SEUniversidad de Navarra · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selenium (Se) compounds are potential therapeutic agents in cancer. Importantly, the biological effects of Se compounds are exerted by their metabolites, with methylselenol (CH₃SeH) being one of the key executors. In this study, we developed a new series of methylselenoesters with different scaffolds aiming to modulate the release of CH₃SeH. The fifteen compounds follow Lipinski's Rule of Five and with exception of compounds

Indexed as

Antineoplastic AgentsApoptosisCaspasesCell DeathCell Line, TumorCell ProliferationDrug Screening Assays, AntitumorEstersFree Radical ScavengersHumansOrganoselenium CompoundsThioredoxin-Disulfide ReductaseAntineoplastic AgentsCaspasesEstersFree Radical ScavengersOrganoselenium CompoundsThioredoxin-Disulfide Reductasecell cycle arrestcell deathcytotoxicitymethylselenoestermethylselenol releasethioredoxin reductase

Identifiers

PMID28767087
PMCPMC6152192
OpenAlexW2739749135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.