ArticleToxins2017
Insights into the Mechanisms Involved in Strong Hemorrhage and Dermonecrosis Induced by Atroxlysin-Ia, a PI-Class Snake Venom Metalloproteinase.
Article in Toxins, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 50 citations in OpenAlex.
- Article
- Dermatopathological findings of Bothrops atrox snakebites: A case series in the Brazilian Amazon.PLoS neglected tropical diseases · 2024Article
- A Complex Pattern of Gene Expression in Tissue Affected by Viperid Snake Envenoming: The Emerging Role of Autophagy-Related Genes.Biomolecules · 2024Article
- Article
- Bothrops (Fer-de-lance) snakebites in the French departments of the Americas (Martinique and Guyana): Clinical and experimental studies and treatment by immunotherapy.PLoS neglected tropical diseases · 2023Review
- Peptide linker increased the stability of pneumococcal fusion protein vaccine candidate.Frontiers in bioengineering and biotechnology · 2023Article
- Comparison of Protein Variation inToxins · 2022Article
- Individual Variability inToxins · 2021Article
- Bleeding and Thrombosis: Insights into Pathophysiology ofInternational journal of molecular sciences · 2021Review
- Review
- P-I metalloproteinases and L-amino acid oxidases fromThe journal of venomous animals and toxins including tropical diseases · 2021Article
- Observational
- Bleeding Disorders inToxins · 2020Observational
- Article
- The relationship between clinics and the venom of the causative Amazon pit viper (Bothrops atrox).PLoS neglected tropical diseases · 2020Article
- Article
- Accuracy of the Lee-White Clotting Time Performed in the Hospital Routine to Detect Coagulopathy inThe American journal of tropical medicine and hygiene · 2018Article
- Antivenom Production againstToxins · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hemorrhage is the most prominent effect of snake venom metalloproteinases (SVMPs) in human envenomation. The capillary injury is a multifactorial effect caused by hydrolysis of the components of the basement membrane (BM). The PI and PIII classes of SVMPs are abundant in viperid venoms and hydrolyze BM components. However, hemorrhage is associated mostly with PIII-class SVMPs that contain non-catalytic domains responsible for the binding of SVMPs to BM proteins, facilitating enzyme accumulation in the tissue and enhancing its catalytic efficiency. Here we report on Atroxlysin-Ia, a PI-class SVMP that induces hemorrhagic lesions in levels comparable to those induced by Batroxrhagin (PIII-class), and a unique SVMP effect characterized by the rapid onset of dermonecrotic lesions. Atroxlysin-Ia was purified from
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.