Evidence map›Paper›PMID 28767037›Full record

ArticleeLife2017

Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution.

Luis Miguel Díaz-Santín, Natasha Lukoyanova, Emir Aciyan, Alan Cm Cheung

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Review
  3. The NuA4 histone acetyltransferase: variations on a theme of SAGA.Nature structural & molecular biology · 2023
    Article
  4. Article
  5. Structure of the NuA4 histone acetyltransferase complex.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Chronicles of the human SAGA co-activator complex.Nature structural & molecular biology · 2021
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Architecture ofCell discovery · 2019
    Article
  19. The Pseudokinase Domain ofG3 (Bethesda, Md.) · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Luis Miguel Díaz-SantínDepartment of Structural and Molecular Biology, Institute of Structural and Molecular Biology, University College London, London, United Kingdom.
Natasha LukoyanovaInstitute of Structural and Molecular Biology, Biological Sciences, Birkbeck College, London, United Kingdom.
Emir AciyanInstitute of Structural and Molecular Biology, Biological Sciences, Birkbeck College, London, United Kingdom.
Alan Cm CheungDepartment of Structural and Molecular Biology, Institute of Structural and Molecular Biology, University College London, London, United Kingdom.ORCID http://orcid.org/0000-0001-6430-5127
Institute of Structural and Molecular Biology · GB

Funding

Wellcome TrustWellcome Trust 079605/2/06/2Wellcome Trust 102535/Z/13/Z
6 · The paper itself

Abstract

Coactivator complexes SAGA and NuA4 stimulate transcription by post-translationally modifying chromatin. Both complexes contain the Tra1 subunit, a highly conserved 3744-residue protein from the Phosphoinositide 3-Kinase-related kinase (PIKK) family and a direct target for multiple sequence-specific activators. We present the Cryo-EM structure of

Indexed as

Amino Acid MotifsBinding SitesChromatinCloning, MolecularCryoelectron MicroscopyDNA, FungalDNA RepairGene ExpressionHistone AcetyltransferasesPlasmidsProtein BindingProtein Conformation, alpha-HelicalProtein Conformation, beta-StrandProtein Interaction Domains and MotifsRecombinant ProteinsSaccharomyces cerevisiaeChromatinDNA, FungalHistone AcetyltransferasesNuA4 protein, S cerevisiaeRecombinant ProteinsSaccharomyces cerevisiae ProteinsSAGA complex, S cerevisiaeTRA1 protein, S cerevisiaeTrans-ActivatorsbiophysicschromatinchromosomescoactivatorgenesNuA4PIKKSAGAS. cerevisiaestructural biologytranscription activation

Identifiers

PMID28767037
PMCPMC5576489
OpenAlexW2740751381

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.