ArticleVirulence2017
Lactobacillus fermentum 3872 as a potential tool for combatting Campylobacter jejuni infections.
Article in Virulence, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- A colon mimetic screening approach reveals Lactobacillus fermentum as a microbiome-based therapy for COPD.NPJ biofilms and microbiomes · 2026Article
- A naturally isolated symbioticCurrent research in microbial sciences · 2026Article
- Meta-analysis of extremotolerant microbes to address nutrient deficiencies in bioregenerative life support systems during Deep-space Missions.NPJ science of food · 2025Article
- The Potential of Lactic Acid Bacteria and Dairy By-Products in ControllingMicroorganisms · 2025Review
- Consortium ofAntibiotics (Basel, Switzerland) · 2024Article
- Anti-Antibiotics (Basel, Switzerland) · 2023Article
- An Overview of the Use and Applications ofMicroorganisms · 2023Review
- Article
- Organic zinc glycine chelate is better than inorganic zinc in improving growth performance of cherry valley ducks by regulating intestinal morphology, barrier function, and the gut microbiome.Journal of animal science · 2023Article
- Article
- Environment-Related Genes Analysis ofFoods (Basel, Switzerland) · 2022Article
- [Research Progress in the Relationship BetweenSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2022Review
- Impact of the gut microecology on Campylobacter presence revealed by comparisons of the gut microbiota from chickens raised on litter or in individual cages.BMC microbiology · 2021Article
- Genomic Analysis ofJournal of fungi (Basel, Switzerland) · 2021Article
- Review
- Lactobacillus Cell Surface Proteins Involved in Interaction with Mucus and Extracellular Matrix Components.Current microbiology · 2020Review
- Chitosan-chelated zinc modulates cecal microbiota and attenuates inflammatory response in weaned rats challenged with Escherichia coli.Journal of microbiology (Seoul, Korea) · 2020Article
- Effects ofVeterinary sciences · 2020Article
- Current Perspectives and Potential of Probiotics to Limit FoodborneFrontiers in microbiology · 2020Review
- Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to the global spread of multidrug resistant pathogenic bacteria, alternative approaches in combating infectious diseases are required. One such approach is the use of probiotics. Lactobacillus fermentum 3872 is a promising probiotic bacterium producing a range of antimicrobial compounds, such as hydrogen peroxide and lactic acid. In addition, previous studies involving genome sequencing and analysis of L. fermentum 3872 allowed the identification of a gene encoding a cell surface protein referred to as collagen binding protein (CBP) (not found in other strains of the species, according to the GenBank database), consisting of a C-terminal cell wall anchor domain (LPXT), multiple repeats of 'B domains' that form stalks presenting an "A domain" required for adhesion. In this study, we found that the CBP of L. fermentum 3872 binds to collagen I present on the surface of the epithelial cells lining the gastrointestinal tract. Moreover, we found that this host receptor is also used for attachment by the major gastrointestinal pathogen, Campylobacter jejuni. Furthermore, we identified an adhesin involved in such interaction and demonstrated that both L. fermentum 3872 and its CBP can inhibit binding of this pathogen to collagen I. Combined with the observation that C. jejuni growth is affected in the acidic environment produced by L. fermentum 3872, the finding provides a good basis for further investigation of this strain as a potential tool for fighting Campylobacter infections.
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