ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2018
Platelet-rich plasma versus exchange intramedullary nailing in treatment of long bone oligotrophic nonunions.
Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Clinical Effectiveness of Platelet-Rich Plasma for Long-Bone Delayed Union and Nonunion: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Cortical allograft strut augmented with platelet-rich plasma for the treatment of long bone non-union in lower limb- a pilot study.BMC musculoskeletal disorders · 2022Trial
- A 44-Year-Old Male Manual Laborer With Nonunion of a Femoral Neck Fracture Treated With Ultrasound-Guided Percutaneous Injections of Platelet-Rich Plasma: A Case Report.The American journal of case reports · 2026Article
- Role of Ortho Biologics in Subtrochanteric Osteotomy Non-union in a Case of Developmental Hip Dysplasia Managed with Total Hip Replacement - A Case Report.Journal of orthopaedic case reports · 2025Article
- Single/ Multiple Dose Percutaneously Injected LR-PRP Enhances Union Rate in Fracture Delayed Unions: A Prospective Case Series.Indian journal of orthopaedics · 2024Article
- Orthobiologics in delayed union and non-union of adult long bones fractures: A systematic review.Bone reports · 2024Review
- Biological aspects to enhance fracture healing.EFORT open reviews · 2023Review
- Therapeutic Efficacy and Safety of Osteoinductive Factors and Cellular Therapies for Long Bone Fractures and Non-Unions: A Meta-Analysis and Systematic Review.Journal of clinical medicine · 2022Review
- Orthobiologics: Current role in Orthopedic Surgery and Traumatology.The archives of bone and joint surgery · 2022Review
- The role of Platelet Rich Plasma and other orthobiologics in bone healing and fracture management: A systematic review.Journal of clinical orthopaedics and trauma · 2022Review
- The Use of Platelet-Rich Plasma (PRP) for the Management of Non-union Fractures.Current osteoporosis reports · 2021Review
- The biology and treatment of acute long-bones diaphyseal fractures: Overview of the current options for bone healing enhancement.Bone reports · 2020Review
- The Treatment of Acute Diaphyseal Long-bones Fractures with Orthobiologics and Pharmacological Interventions for Bone Healing Enhancement: A Systematic Review of Clinical Evidence.Bioengineering (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of the study was to evaluate the effects of platelet-rich plasma on healing rates and healing time in the treatment of long bone nonunions treated by an intramedullary nail previously. MATERIALS AND
methodsBetween August 2008 and January 2012, 14 consecutive patients who were treated for long bone nonunions with percutaneous platelet-rich plasma application (PRP) were included in the study. The control group included 15 consecutive patients who were treated with exchange intramedullary nailing (EIN). In the postoperative period, all patients were controlled in every 2 weeks clinically and in every 4 weeks radiologically. Patients were evaluated with visual analog scale (VAS) in preoperative and postoperative periods.
resultsThe mean healing time was shorter in PRP group as 16.71 ± 2.4 weeks compared with that of 19.07 ± 3.67 weeks in EIN group (p = 0.053). At the end of the follow-up, the union is achieved in 92.8% of the cases in PRP group. This ratio was 80% in control group. The mean VAS values in preoperative and postoperative periods were not statistically significant in both groups (p > 0.05). When PRP and control groups were evaluated individually, the postoperative VAS was lower than that of preoperative VAS in both groups (p = 0.0001 and p = 0.0001, respectively).
conclusionPercutaneous PRP application significantly affected union rate, but no significant difference found when compared to EIN in the treatment of oligotrophic nonunions after intramedullary nailing of long bone fractures. PRP can be applied as a minimally invasive and safe method of saving resources in medical care instead of EIN.
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Registered trials
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