ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2018
Pediatric soft tissue sarcoma of the limbs: clinical outcome of 97 patients.
Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 13 citations in OpenAlex.
- Pediatric tonsillar synovial sarcoma: extremely rare case report.Frontiers in pediatrics · 2025Article
- Magnetic resonance imaging of soft tissue sarcoma: features related to prognosis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2021Review
- The Biology of Synovial Sarcoma: State-of-the-Art and Future Perspectives.Current treatment options in oncology · 2021Review
- A review of paediatric soft tissues masses referred to a tertiary musculoskeletal sarcoma centre.The British journal of radiology · 2021Article
- Precision Medicine in Soft Tissue Sarcoma Treatment.Cancers · 2020Review
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
purposeSoft tissue sarcomas (STS) of the extremities in children are a heterogeneous group of tumors with a very different prognosis for which optimal treatment remains controversial. PATIENTS AND
methodsWe retrospectively evaluated 97 patients younger than 15 years old affected by limb soft tissue sarcomas. All cases were histologically revised, and tumor grade was assessed according to the FNLCC system. Thirty-two were rhabdomyosarcoma (RMS) and 65 non-rhabdomyosarcoma (NRMSTS); among these, 40 (61.5%) were grade 3 according to FNLCC classification. Overall survival, local recurrence and distant metastasis were analyzed.
resultsOverall survival was 77.8% at 5 years and 69.7% at 10 years. Among grade 3 tumors, RMS had a worse prognosis over NRSTS. Similarly, tumors larger than 5 cm had a worse prognosis compared to smaller ones. Local recurrence-free survival was 90.7% at 5 years and 87.1% at 10 years with a better local control in grade 3 NRSTS over RMS and in tumors smaller than 2 cm.
conclusionChildren affected by extremities RMS were confirmed to have the worst prognosis, in particular in case of metastasis at presentation. Differently from adult patients, hand and feet locations are frequent site for STS and 2 cm diameter should be taken as cut off for higher risk of LR. Similarly to adulthood STS, grading correlates with prognosis in NRSTS. The identification of prognostic variables should enable risk-adapted therapies to be planned.
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