ArticleEcoHealth2017
Host Responses to Pathogen Priming in a Natural Songbird Host.
Article in EcoHealth, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Hard to handle: infected house finches do not prefer easier-to-consume food.Animal behaviour · 2026Article
- Prior pathogen exposure augments inter-individual heterogeneity in antibody levels and reinfection loads in a songbird-pathogen system.Scientific reports · 2026Article
- Host Prior Exposure Augments Gene Expression Heterogeneity of Both Host and Pathogen During In Vivo Infection.Molecular ecology · 2026Article
- Paying Upfront: Successful Initial Infections Protect Against Severe Future Infections.Integrative organismal biology (Oxford, England) · 2026Article
- Host prior exposure augments heterogeneity in gene expression in both host and pathogen duringbioRxiv : the preprint server for biology · 2025Article
- Reinfection with a Bacterial Pathogen Augments Heterogeneity in Host Disease Responses.Research square · 2025Article
- Pathogen priming alters host transmission potential and predictors of transmissibility in a wild songbird species.mSphere · 2025Article
- Microbial surveillance versus cytokine responsiveness in native and non-native house sparrows.Biology letters · 2025Article
- Pathogen priming alters host transmission potential and predictors of transmissibility in a wild songbird species.bioRxiv : the preprint server for biology · 2024Article
- Prior exposure to pathogens augments host heterogeneity in susceptibility and has key epidemiological consequences.PLoS pathogens · 2024Article
- Prior exposure to pathogens augments host heterogeneity in susceptibility and has key epidemiological consequences.bioRxiv : the preprint server for biology · 2024Article
- Detecting and quantifying heterogeneity in susceptibility using contact tracing data.PLoS computational biology · 2024Article
- Incomplete immunity in a natural animal-microbiota interaction selects for higher pathogen virulence.Current biology : CB · 2024Article
- Protection Generated by Prior Exposure to Pathogens Depends on both Priming and Challenge Dose.Infection and immunity · 2022Article
- Article
- Disease tolerance alters host competence in a wild songbird.Biology letters · 2021Article
- Host population dynamics in the face of an evolving pathogen.The Journal of animal ecology · 2021Article
- Host exposure history modulates the within-host advantage of virulence in a songbird-bacterium system.Scientific reports · 2019Article
- Characterization of unilateral conjunctival inoculation with Mycoplasma gallisepticum in house finches.Avian pathology : journal of the W.V.P.A · 2018Article
- Feeder density enhances house finch disease transmission in experimental epidemics.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Hosts in free-living populations can experience substantial variation in the frequency and dose of pathogen exposure, which can alter disease progression and protection from future exposures. In the house finch-Mycoplasma gallisepticum (MG) system, the pathogen is primarily transmitted via bird feeders, and some birds may be exposed to frequent low doses of MG while foraging. Here we experimentally determined how low dose, repeated exposures of house finches to MG influence host responses and protection from secondary high-dose challenge. MG-naive house finches were given priming exposures that varied in dose and total number. After quantifying host responses to priming exposures, all birds were given a secondary high-dose challenge to assess immunological protection. Dose, but not the number of exposures, significantly predicted both infection and disease severity following priming exposure. Furthermore, individuals given higher priming doses showed stronger protection upon secondary, high-dose challenge. However, even single low-dose exposures to MG, a proxy for what some birds likely experience in the wild while feeding, provided significant protection against a high-dose challenge. Our results suggest that bird feeders, which serve as sources of infection in the wild, may in some cases act as "immunizers," with important consequences for disease dynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.