ReviewJournal of neural transmission (Vienna, Austria : 1996)2018
The role of the basal ganglia in the control of seizure.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 89 citations in OpenAlex.
- Lingual Dyskinesia Developing after the First Dose of Methylphenidate Treatment in a Child with Neurodevelopmental Disorders: Genetic Predispositions.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- An update on the network theory of epilepsy.Frontiers in network physiology · 2026Article
- Associations of Late-Onset Epilepsy With Myocardial Infarction and Nonstroke Vascular Death.Neurology · 2025Article
- Dysfunctional LHX6 pallido-subthalamic projections mediate epileptic events in a mouse model of Leigh syndrome.The Journal of clinical investigation · 2025Article
- Molecular imaging based biophysical changes of striatum closely associated with cognitive impairment in childhood self-limited epilepsy with centrotemporal spikes.European journal of nuclear medicine and molecular imaging · 2025Article
- Focused ultrasound suppresses pentylenetetrazol-induced epileptiform activity in rats and alters connectivity measured by functional MRI.Scientific reports · 2025Article
- Multiple subcortical and subcortico-cortico dynamic network reconfigurations characterize focal-to-bilateral tonic-clonic seizures.Scientific reports · 2025Article
- Absence seizures: Update on signaling mechanisms and networks.Epilepsia open · 2025Article
- Individualized morphological covariation network aberrance associated with seizure relapse after antiseizure medication withdrawal.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Post-encephalitic epilepsy in patients with acute encephalopathy with biphasic seizures and late reduced diffusion.Frontiers in neurology · 2025Article
- Partial correlation as a tool for mapping functional-structural correspondence in human brain connectivity.Network neuroscience (Cambridge, Mass.) · 2025Article
- Article
- New and Old Targets: Evolving Framework for Personalized DBS in Refractory Epilepsy.Stereotactic and functional neurosurgery · 2025Review
- Striatum is the potential target for treating absence epilepsy: a theoretical evidence.Cognitive neurodynamics · 2024Article
- Progressive postoperative atrophy of ipsilateral thalamus, putamen, and globus pallidus in patients with temporal lobe epilepsy: A volumetric analysis.Epilepsia open · 2024Article
- Transcranial brain parenchyma sonography in patients with juvenile myoclonic epilepsy.Acta neurologica Belgica · 2024Article
- Seizure onset and offset pattern determine the entrainment of the cortex and substantia nigra in the nonhuman primate model of focal temporal lobe seizures.bioRxiv : the preprint server for biology · 2024Article
- Article
- Volume-based structural connectome of epilepsy partialis continua in Rasmussen's encephalitis.Brain communications · 2024Article
- Optogenetic stimulation of the superior colliculus suppresses genetic absence seizures.Brain : a journal of neurology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Epilepsy is a network disorder and each type of seizure involves distinct cortical and subcortical network, differently implicated in the control and propagation of the ictal activity. The role of the basal ganglia has been revealed in several cases of focal and generalized seizures. Here, we review the data that show the implication of the basal ganglia in absence, temporal lobe, and neocortical seizures in animal models (rodent, cat, and non-human primate) and in human. Based on these results and the advancement of deep brain stimulation for Parkinson's disease, basal ganglia neuromodulation has been tested with some success that can be equally seen as promising or disappointing. The effect of deep brain stimulation can be considered promising with a 76% in seizure reduction in temporal lobe epilepsy patients, but also disappointing, since only few patients have become seizure free and the antiepileptic effects have been highly variable among patients. This variability could probably be explained by the heterogeneity among the patients included in these clinical studies. To illustrate the importance of specific network identification, electrophysiological activity of the putamen and caudate nucleus has been recorded during penicillin-induced pre-frontal and motor seizures in one monkey. While an increase of the firing rate was found in putamen and caudate nucleus during pre-frontal seizures, only the activity of the putamen cells was increased during motor seizures. These preliminary results demonstrate the implication of the basal ganglia in two types of neocortical seizures and the necessity of studying the network to identify the important nodes implicated in the propagation and control of each type of seizure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.