ArticleClinical and experimental nephrology2018
Ratio of blood urea nitrogen to serum creatinine at initiation of dialysis is associated with mortality: a multicenter prospective cohort study.
Article in Clinical and experimental nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04612595 (The Association Between Serum Urea Nitrogen to Creatinine Ratio and the Survival in Patients With DKD), which is not on this map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Association Between Serum Urea Nitrogen to Creatinine Ratio and the Survival in Patients With DKD
Who cites it
16 citing papers in PubMed.
- Renal function dynamics in COVID-19: exploring biomarker interactions with D-dimer and C-reactive proteins.Bioscience reports · 2026Article
- Association between blood urea nitrogen-to-creatinine ratio and 28-day mortality in acute kidney injury patients undergoing continuous renal replacement therapy.Scientific reports · 2025Article
- Association Between the Blood Urea Nitrogen-to-Creatinine Ratio Trajectories and Clinical Outcomes in Critically Ill Hemorrhagic Stroke Patients: Insights from MIMIC-IV Database.Journal of clinical medicine · 2025Article
- Trajectories of urea‑to‑creatinine ratio and risk of clinical outcomes in survivors of acute kidney disease: a population-based study.Clinical kidney journal · 2025Article
- A nomogram model incorporating blood biomarkers predicts 3-week functional outcomes in stroke patients.Frontiers in neuroscience · 2025Article
- Clinical implications of persistently increased blood urea nitrogen/serum creatinine ratio (PI-BUN/Cr) in severe COVID-19 patients.Pneumonia (Nathan Qld.) · 2024Article
- Article
- Clinical practice guidelines for nutritional assessment and monitoring of adult ICU patients in China.Journal of intensive medicine · 2024Article
- Plasma urea:creatinine ratio as a biomarker of gastrointestinal bleeding in dogs with anaemia.Veterinary medicine and science · 2023Article
- Blood urea nitrogen to creatinine ratio and long-term survival in patients with chronic heart failure.European journal of medical research · 2023Article
- Relationship between BUN/Cr and Prognosis of HF Across the Full Spectrum of Ejection Fraction.Arquivos brasileiros de cardiologia · 2023Article
- Analysis of patency rates and factors associated with arteriovenous fistula in maintenance hemodialysis patients followed for 10 years.Renal failure · 2023Article
- Elevated serum urea-to-creatinine ratio is associated with adverse inpatient clinical outcomes in non-end stage chronic kidney disease.Scientific reports · 2022Article
- Low Serum Albumin Is Associated with Poor Prognosis in Patients Receiving Peritoneal Dialysis Treatment.Journal of healthcare engineering · 2022Article
- Renal markers and risks of all cause and cardiovascular mortality from the Taichung community based cohort study.Scientific reports · 2021Article
- Blood urea nitrogen/creatinine change ratio as a delta check method for dialysis specimens.International journal of clinical and experimental pathology · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome studies have shown that the estimated glomerular filtration rate (eGFR) at the time of initiating dialysis was associated with mortality. However, the relationship between ratio of blood urea nitrogen to serum creatinine (BUN/Cr) and mortality is unknown.
methodsThe study was a multicenter, prospective cohort analysis including 1520 patients. Patients were classified into four quartiles based on the BUN/Cr ratio at the dialysis initiation, with Q1 having the lowest ratio and Q4 the highest. All-cause mortality after initiating dialysis was compared using the log-rank test. All-cause mortality of Q1, Q2, and Q3 was compared with that of Q4 using multivariate Cox proportional hazard regression analysis. Moreover, we compared the renal parameters including BUN/Cr ratio, eGFR, and creatinine clearance for sensitivity and specificity using receiver operative characteristic (ROC) curve.
resultsSignificant differences were observed in all-cause mortality among the four groups (p < 0.001). Multivariate analysis revealed that all-cause mortality was significantly higher in Q4 than in Q1 [hazard ratio (HR) = 1.82, 95% confidence interval (CI) 1.24-2.67, p = 0.002]. The increase in BUN/Cr ratio was positively associated with mortality (HR 1.04, 95% CI 1.02-1.06, p = 0.002). The sensitivity and specificity of BUN/Cr ratio for 180, 365, 730, and 1095 days mortality ranged between 0.60-0.72 and 0.59-0.71, respectively. The area under the curve of BUN/Cr for all-cause mortality was the highest among the renal parameters.
conclusionThe BUN/Cr ratio at the time of initiation of dialysis was associated with all-cause mortality.
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