ArticleVirchows Archiv : an international journal of pathology2018
Evaluation of the budding and depth of invasion (BD) model in oral tongue cancer biopsies.
Article in Virchows Archiv : an international journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tumour budding in oral squamous cell carcinoma: a meta-analysis.British journal of cancer · 2018Pooled it
- Evaluating Depth of Invasion as a Continuous Prognostic Factor in Oral Squamous Cell Carcinoma.Head & neck · 2025Article
- Optimizing Prognostic Assessment in High-Risk Head and Neck Squamous Cell Carcinomas: The Impact of Tumor Budding and a Novel Histomorphological Scoring System.Cancer medicine · 2025Article
- Web-based prognostic tools for oral tongue cancer: An analysis of online predictors.Oral diseases · 2024Article
- Treatment strategy for cervical lymph node metastases from early-stage tongue and floor of the mouth squamous cell carcinoma using tumour budding and depth of invasion as predictors.Clinical oral investigations · 2024Article
- A Correlation of Tumour Budding and Tumour-Stroma Ratio with Clinicopathological Factors in Oral Squamous Cell Carcinoma.Sultan Qaboos University medical journal · 2024Article
- Predictive value of tumor budding in head and neck squamous cell carcinoma: an update.Virchows Archiv : an international journal of pathology · 2023Review
- Microvascular density and tumor budding in oral squamous cell carcinoma.Medicina oral, patologia oral y cirugia bucal · 2023Article
- Review
- Oral cancer: changing the aim of the biopsy in the age of precision medicine. A review.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2021Review
- Staging more important than grading? Evaluation of malignancy grading, depth of invasion, and resection margins in oral squamous cell carcinoma.Clinical oral investigations · 2021Article
- Tumour budding in solid cancers.Nature reviews. Clinical oncology · 2021Review
- Survival analysis of recurrent squamous cell carcinoma of the lower oral cavity treated by surgery.International journal of clinical and experimental pathology · 2021Article
- Epidemiology and pathology of oral squamous cell carcinoma in a multi-ethnic population: Retrospective study of 154 cases over 7 years in Qatar.Annals of medicine and surgery (2012) · 2020Article
- Human myoma tissue-based extracellular matrix models for testing the effects of irradiation on the HPV positive cells.Virology journal · 2020Article
- Tumor budding score predicts lymph node status in oral tongue squamous cell carcinoma and should be included in the pathology report.PloS one · 2020Article
- Immunolocalization of Cancer Stem Cells Marker ALDH1 and its Association with Tumor Budding in Oral Squamous Cell Carcinoma.Head and neck pathology · 2019Article
- The updated AJCC/TNM staging system (8Translational cancer research · 2019Article
- Extracellular vesicles derived from cancer-associated fibroblasts induce the migration and invasion of oral squamous cell carcinoma.Journal of extracellular vesicles · 2019Article
- Small oral tongue cancers (≤ 4 cm in diameter) with clinically negative neck: from the 7th to the 8th edition of the American Joint Committee on Cancer.Virchows Archiv : an international journal of pathology · 2018Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is of great clinical importance to identify simple prognostic markers from preoperative biopsies that could guide treatment planning. Here, we compared tumor budding (B), depth of invasion (D), and the combined scores (i.e., budding and depth of invasion (BD) histopathologic model) in preoperative biopsies and the corresponding postoperative specimens of oral tongue squamous cell carcinoma (OTSCC). Tumor budding and depth of invasion were evaluated in the pre- and postoperative samples from 100 patients treated for OTSCC. Sensitivity and specificity statistics were used. Our results showed statistically significant (P < 0.001) relationship between pre- and postoperative BD scores. There was an agreement between the pre- and postoperative BD model scores in 83 cases (83%) with 57.1% sensitivity (95% CI 39.4 to 73.7%) and 96.9% specificity (95% CI 89.3 to 99.6%). Our findings suggest that the BD model, analyzed from representative biopsies, could be used for the treatment planning of OTSCC.
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