ArticleMolecular medicine reports2017
IL‑33 restricts invasion and adhesion of trophoblast cell line JEG3 by downregulation of integrin α4β1 and CD62L.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Maternal IL-33 critically regulates tissue remodeling and type 2 immune responses in the uterus during early pregnancy in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy.Frontiers in cell and developmental biology · 2021Article
- Dynamic Expression of Interleukin-33 and ST2 in the Mouse Reproductive Tract Is Influenced by Superovulation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- Expression of IL-33 Receptor Is Significantly Up-Regulated in B Cells During Pregnancy and in the Acute Phase of Preterm Birth in Mice.Frontiers in immunology · 2020Article
- Screening of a Novel Upregulated lncRNA, A2M-AS1, That Promotes Invasion and Migration and Signifies Poor Prognosis in Breast Cancer.BioMed research international · 2020Article
- High level of interleukin-33 in cancer cells and cancer-associated fibroblasts correlates with good prognosis and suppressed migration in cholangiocarcinoma.Journal of Cancer · 2020Article
- Observational
- Engineered nanomaterial applications in perinatal therapeutics.Pharmacological research · 2018Review
- miR-518b Enhances Human Trophoblast Cell Proliferation Through Targeting Rap1b and Activating Ras-MAPK Signal.Frontiers in endocrinology · 2018Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-33 (IL-33) promotes migration of cancer cells through downregulating the expression of E-cadherin. Previous studies have demonstrated that IL‑33 stimulates the proliferation of trophoblasts. However, the effect of IL‑33 on the adhesion and invasion of trophoblasts has not been investigated in detail. In the present study, the expression of IL‑33 and its receptor, IL‑1 receptor‑like 1 (ST2), was examined in villi from women during early pregnancy using immunohistochemistry. ST2 expression on human trophoblast and choriocarcinoma cell lines JAR, BeWo, JEG3 and HTR8 was confirmed by flow cytometry (FCM) assay. The effect of recombinant human IL‑33 (rhIL‑33) on adhesion, invasion and associated molecules was analyzed by cell adhesion, Matrigel invasion and FCM assays. The current study identified that human trophoblasts expressed IL‑33 and ST2. RhIL‑33 inhibited trophoblast invasion and adhesion, and decreased adhesion and invasion‑associated molecules such as integrin α4β1 and CD62L. Therefore, these results suggest that IL‑33 may serve an important role in limiting invasion and implantation of trophoblasts by adhesion and invasion‑associated molecules, contributing to the formation of the placenta and maintenance of normal pregnancy during early pregnancy.
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