ArticleInternational journal of spine surgery2017
Fortifying the Bone-Implant Interface Part 1: An In Vitro Evaluation of 3D-Printed and TPS Porous Surfaces.
Article in International journal of spine surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- How surface coatings on titanium implants affect keratinized tissue: A systematic review.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Pooled it
- Prospective Trial of Sacroiliac Joint Fusion Using 3D-Printed Triangular Titanium Implants.Medical devices (Auckland, N.Z.) · 2020Trial
- Three-Dimensional Printing of a Spinal Interbody: Design Principles, Biomaterials, and Translational Considerations.Journal of functional biomaterials · 2026Review
- The rational design, biofunctionalization and biological properties of orthopedic porous titanium implants: a review.Frontiers in bioengineering and biotechnology · 2025Review
- Surface Functionalization of Titanium-Based Implants with a Nanohydroxyapatite Layer and Its Impact on Osteoblasts: A Systematic Review.Journal of functional biomaterials · 2024Review
- 3D printing for spine pathologies: a state-of-the-art review.Biomedical engineering letters · 2023Review
- Comparative studyWorld journal of orthopedics · 2023Article
- An additively manufactured titanium tilting suture anchor: a biomechanical assessment on human and ovine bone specimens.Frontiers in surgery · 2023Article
- Minimally Invasive Sacroiliac Fusion-a Review.Current pain and headache reports · 2022Review
- Biomaterials for Interbody Fusion in Bone Tissue Engineering.Frontiers in bioengineering and biotechnology · 2022Review
- Can activated titanium interbody cages accelerate or enhance spinal fusion? a review of the literature and a design for clinical trials.Journal of materials science. Materials in medicine · 2021Review
- Mid- and Long-Term Follow-Up Efficacy Analysis of 3D-Printed Interbody Fusion Cages for Anterior Cervical Discectomy and Fusion.Orthopaedic surgery · 2021Article
- Multifunctional Coatings of Titanium Implants Toward Promoting Osseointegration and Preventing Infection: Recent Developments.Frontiers in bioengineering and biotechnology · 2021Review
- Trends in lumbar spinal fusion-a literature review.Journal of spine surgery (Hong Kong) · 2020Review
- Sagittal en bloc resection of primary tumors in the thoracic and lumbar spine: feasibility, safety and outcome.Scientific reports · 2020Article
- Minimally invasive lateral transiliac sacroiliac joint fusion using 3D-printed triangular titanium implants.Medical devices (Auckland, N.Z.) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn aging society and concomitant rise in the incidence of impaired bone health have led to the need for advanced osteoconductive spinal implant surfaces that promote greater biological fixation (
methodsThis study investigated the response of human osteoblasts to additive manufactured (AM) trabecular-like titanium implant surfaces compared to traditionally machined base material with titanium plasma spray (TPS) coated surfaces, with and without a nanocrystalline hydroxyapatite (HA) coating. For TPS-coated discs, wrought Ti6Al4V ELI was machined and TPS-coating was applied. For AM discs, Ti6Al4V ELI powder was 3D-printed to form a solid base and trabecular-like porous surface. The HA-coating was applied via a precipitation dip-spin method. Surface porosity, pore size, thickness, and hydrophilicity were characterized. Initial cell attachment, proliferation, alkaline phosphatase (ALP) activity, and calcium production of hFOB cells (
resultsCells on AM discs exhibited expedited proliferative activity. While there were no differences in mean ALP expression and calcium production between TPS and AM discs, calcium production on the AM discs trended 48% higher than on TPS discs (
conclusionsResults demonstrate that additive manufacturing allows for controlled trabecular-like surfaces that promote earlier cell proliferation and trends toward higher calcium production than TPS coating. Results further showed that nanocrystalline HA may not provide an advantage on porous titanium surfaces. CLINICAL RELEVANCE: Additive manufactured porous titanium surfaces may induce a more osteogenic environment compared to traditional TPS, and thus present as an attractive alternative to TPS-coating for orthopedic spinal implants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.