Evidence map›Paper›PMID 28765761›Full record

ArticleJournal of arrhythmia2017

Simulation of ventricular rate control during atrial fibrillation using ionic channel blockers.

Shin Inada, Nitaro Shibata Md PhD, Michiaki Iwata PhD, Ryo Haraguchi PhD, Takashi Ashihara Md PhD, Takanori Ikeda Md PhD, Kazuyuki Mitsui PhD, Halina Dobrzynski PhD, Mark R Boyett PhD, Kazuo Nakazawa PhD

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of arrhythmia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Characterisation of human AV-nodal properties using a network model.Medical & biological engineering & computing · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 2 countries.

Shin InadaHimeji Dokkyo University, Himeji, Hyogo, Japan.
Nitaro Shibata Md PhDShinjuku Mitsui Building Clinic, Tokyo, Japan.
Michiaki Iwata PhDJapan Agency for Medical Research and Development, Tokyo, Japan.
Ryo Haraguchi PhDGraduate School of Applied Informatics, University of Hyogo, Kobe, Hyogo, Japan.
Takashi Ashihara Md PhDDepartment of Cardiovascular Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.
Takanori Ikeda Md PhDDepartment of Cardiovascular Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
Kazuyuki Mitsui PhDGraduate School of Advanced Science and Technology, Tokyo Denki University, Tokyo, Japan.
Halina Dobrzynski PhDInstitute of Cardiovascular Medicine, University of Manchester, Manchester, United Kingdom.
Mark R Boyett PhDInstitute of Cardiovascular Medicine, University of Manchester, Manchester, United Kingdom.
Kazuo Nakazawa PhDNational Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
University of Manchester · GBHimeji Dokkyo University · JPJapan Agency for Medical Research and Development · JPMitsui (Japan) · JPNational Cerebral and Cardiovascular Center · JPShiga University of Medical Science · JPToho University · JPTokyo Denki University · JPUniversity of Hyogo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe atrioventricular (AV) node is the only compartment that conducts an electrical impulse between the atria and the ventricles. The main role of the AV node is to facilitate efficient pumping by conducting excitation slowly between the two chambers as well as reduce the ventricular rate during atrial fibrillation (AF).

methodsUsing computer simulations, we investigated excitation conduction from the right atrium to the bundle of His during high-rate atrial excitation with or without partial blocking of the calcium or potassium ionic current.

resultsOur simulations revealed differences in rate reduction and repolarization effects between calcium and potassium current blocking and high degree of potassium current blocking required to reduce the ventricular rate during AF.

conclusionsOur simulation results explain why potassium current blockers are not recommended for controlling ventricular rate during AF.

Indexed as

ArrhythmiaAtrial fibrillationCardiac conduction systemComputer simulationVentricular rate control

Identifiers

PMID28765761
PMCPMC5529332
OpenAlexW2580499703

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.