Evidence map›Paper›PMID 28765759›Full record

ArticleJournal of arrhythmia2017

Current use of direct oral anticoagulants for atrial fibrillation in Japan: Findings from the SAKURA AF Registry.

Yasuo Okumura, Katsuaki Yokoyama, Naoya Matsumoto, Eizo Tachibana, Keiichiro Kuronuma, Koji Oiwa, Michiaki Matsumoto, Toshiaki Kojima, Shoji Hanada, Kazumiki Nomoto and 12 more

Abstract read
In one paragraph

Article in Journal of arrhythmia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. An Updated Pooled Analysis of Off-Label Under and Over-Dosed Direct Oral Anticoagulants in Patients with Atrial Fibrillation.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Pooled it
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Article
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Yasuo OkumuraDivision of Cardiology, Nihon University Itabashi Hospital, 30-1 Ohyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
Katsuaki YokoyamaDepartment of Cardiology, Nihon University Hospital, Tokyo, Japan.
Naoya MatsumotoDepartment of Cardiology, Nihon University Hospital, Tokyo, Japan.
Eizo TachibanaKawaguchi Municipal Medical Center, Saitama, Japan.
Keiichiro KuronumaKawaguchi Municipal Medical Center, Saitama, Japan.
Koji OiwaYokohama Chuo Hospital, Kanagawa, Japan.
Michiaki MatsumotoYokohama Chuo Hospital, Kanagawa, Japan.
Toshiaki KojimaSekishindo Hospital, Saitama, Japan.
Shoji HanadaAsakadai Central General Hospital, Saitama, Japan.
Kazumiki NomotoTokyo Rinkai Hospital, Tokyo, Japan.
Ken ArimaKasukabe Municipal Hospital, Saitama, Japan.
Fumiyuki TakahashiYasuda Hospital, Tokyo, Japan.
Tomobumi KotaniMakita General Hospital, Tokyo, Japan.
Yukitoshi IkeyaItabashi Medical Association Hospital, Tokyo, Japan.
Seiji FukushimaUkima Central Hospital, Tokyo, Japan.
Satoru ItohItou Cardiovascular Clinic, Saitama, Japan.
Kunio KondoKondo Clinic, Tokyo, Japan.
Masaaki ChikuKeiai Clinic, Tokyo, Japan.
Yasumi OhnoOhno Medical Clinic, Tokyo, Japan.
Motoyuki OnikuraOnikura Clinic, Chiba, Japan.
Atsushi HirayamaDivision of Cardiology, Nihon University Itabashi Hospital, 30-1 Ohyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan.
The Sakura Af Registry InvestigatorsDivision of Cardiology, Nihon University Itabashi Hospital, 30-1 Ohyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLarge-scale investigations on the use of oral anticoagulants including direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) have not included Japanese patients.

methodsWe established the multicenter SAKURA AF Registry to support prospective observational research on the status of anticoagulation treatment, especially with DOAC, for AF in Japan. We enrolled 3266 AF patients treated with warfarin (

resultsWe conducted our first analysis of the registry data, and although we found equivalent mean age between the DOAC and warfarin users (71.8±9.5 vs. 72.3±9.4 years,

conclusionsOur initial analysis of the SAKURA AF Registry data clarified the real-world use of anticoagulants, which includes DOACs and warfarin in Japan. The DOAC users were at a lower risk for stroke than the warfarin users. In 20-30% of DOAC users, the dose was inappropriately reduced.

Indexed as

Atrial fibrillationDirect oral anticoagulantsSAKURA AF RegistryWarfarin

Identifiers

PMID28765759
PMCPMC5529323

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.