Evidence map›Paper›PMID 28765714›Full record

ArticleClinical and experimental gastroenterology2017

High prevalence of subclass-specific binding and neutralizing antibodies against

Tanya M Monaghan, Ola H Negm, Brendon MacKenzie, Mohamed R Hamed, Clifford C Shone, David P Humphreys, K Ravi Acharya, Mark H Wilcox

Open access · goldAbstract read
In one paragraph

Article in Clinical and experimental gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Observational
  2. Luminal Gastrointestinal Manifestations of Cystic Fibrosis.Current gastroenterology reports · 2021
    Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Tanya M MonaghanNottingham Digestive Diseases Centre, NIHR Nottingham Digestive Diseases Biomedical Research Unit, School of Medicine, University of Nottingham, Nottingham.
Ola H NegmBreast Surgery Group, Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Brendon MacKenzieAntibody Biology, UCB-New Medicines, UCB Celltech, Slough, UK.
Mohamed R HamedBreast Surgery Group, Division of Medical Sciences and Graduate Entry Medicine, School of Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, UK.
Clifford C ShoneToxins Group, National Infection Service, Public Health England, Salisbury, UK.
David P HumphreysAntibody Biology, UCB-New Medicines, UCB Celltech, Slough, UK.
K Ravi AcharyaDepartment of Biology and Biochemistry, University of Bath, Bath, UK.
Mark H WilcoxLeeds Institute of Biomedical and Clinical Sciences, University of Leeds, Leeds, UK.
UCB Pharma (United Kingdom) · GBMansoura University · EGNIHR Nottingham Digestive Diseases Biomedical Research Unit · GBPublic Health England · GBQueen's Medical Centre · GBUniversity of Bath · GBUniversity of Leeds · GB

Funding

Medical Research Council MR/K027123/1
6 · The paper itself

Abstract

objectivesDespite multiple risk factors and a high rate of colonization for

methodsSubclass-specific IgA and IgG responses to highly purified whole

resultsSerum IgA anti-toxin A and B levels and neutralizing antibodies against toxin A were significantly higher in adult cystic fibrosis patients (n=16) compared with healthy controls (n=17) and patients with symptomatic

conclusionA superior ability to generate robust humoral immunity to

Indexed as

antibodiesClostridium difficilecystic fibrosis

Identifiers

PMID28765714
PMCPMC5525456
OpenAlexW2739091355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.