ArticleBritish journal of cancer2017
Vitamin D receptor and calcium-sensing receptor polymorphisms and colorectal cancer survival in the Newfoundland population.
Article in British journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Pooled it
- Article
- Associations between polymorphisms in leptin and leptin receptor genes and colorectal cancer survival.Cancer biology & medicine · 2023Article
- Vitamin D receptor absence does not enhance intestinal tumorigenesis in ApcPirc/+rats.Biology open · 2022Article
- Vitamin D Receptor (Nutrients · 2021Article
- Comparative Study of Organoids from Patient-Derived Normal and Tumor Colon and Rectal Tissue.Cancers · 2020Article
- Serum vitamin D receptor (VDR) levels as a potential diagnostic marker for colorectal cancer.Saudi journal of biological sciences · 2020Article
- KMP01D Demonstrates Beneficial Anti-inflammatory Effects on Immune Cells: AnFrontiers in immunology · 2020Article
- Vitamin D receptor expression in peripheral blood mononuclear cells is inversely associated with disease activity and inflammation in lupus patients.Clinical rheumatology · 2019Article
- Repurposing vitamin D for treatment of human malignanciesActa pharmaceutica Sinica. B · 2019Review
- Calcium-sensing receptor in colorectal inflammation and cancer: Current insights and future perspectives.World journal of gastroenterology · 2018Review
- The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention.Journal of ovarian research · 2018Review
- Gut microbial metabolites and its impact on human health.Annals of gastroenterologyReview
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreased serum levels of vitamin D and calcium have been associated with lower risks of colorectal cancer (CRC) incidence and mortality. These inverse associations may be mediated by the vitamin D receptor (VDR) and the calcium-sensing receptor (CASR). We investigated genetic variants in VDR and CASR for their relevance to CRC prognosis.
methodsA population-based cohort of 531 CRC patients diagnosed from 1999 to 2003 in Newfoundland and Labrador, Canada, was followed for mortality and cancer recurrence until April 2010. Germline DNA samples were genotyped with the Illumina Omni-Quad 1 Million chip. Multivariate Cox models assessed 41 tag single-nucleotide polymorphisms and relative haplotypes on VDR and CASR in relation to all-cause mortality (overall survival, OS) and disease-free survival (DFS).
resultsGene-level associations were observed between VDR and the DFS of rectal cancer patients (P=0.037) as well as between CASR and the OS of colon cancer patients (P=0.014). Haplotype analysis within linkage blocks of CASR revealed the G-G-G-G-G-A-C haplotype (rs10222633-rs10934578-rs3804592-rs17250717-A986S-R990G-rs1802757) to be associated with a decreased OS of colon cancer (HR, 3.15; 95% CI, 1.66-5.96). Potential interactions were seen among prediagnostic dietary calcium intake with the CASR R990G (P
conclusionsPolymorphic variations in VDR and CASR may be associated with survival after a diagnosis of CRC.
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