ArticleScientific reports2017
The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Review
- P-glycoprotein expression skews mitochondrial dye measurements in T cells.Frontiers in immunology · 2025Article
- Markers and makers of NKT17 cells.Experimental & molecular medicine · 2023Review
- RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development.Frontiers in immunology · 2023Article
- Article
- Modulation of TCR signalling components occurs prior to positive selection and lineage commitment in iNKT cells.Scientific reports · 2021Article
- Drivers of Inflammation in Psoriatic Arthritis: the Old and the New.Current rheumatology reports · 2021Review
- Natural Killer T Lymphocytes Integrate Innate Sensory Information and Relay Context to Effector Immune Responses.Critical reviews in immunology · 2021Review
- Intravital imaging of interactions between iNKT and kupffer cells to clear free lipids during steatohepatitis.Theranostics · 2021Article
- The miR-183/96/182 Cluster Regulates the Functions of Corneal Resident Macrophages.ImmunoHorizons · 2020Article
- Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions.The Journal of experimental medicine · 2020Article
- High Frequency of Gamma Interferon-Producing PLZFJournal of virology · 2020Article
- The Roles of RUNX Family Proteins in Development of Immune Cells.Molecules and cells · 2020Review
- Quantitative Difference in PLZF Protein Expression Determines iNKT Lineage Fate and Controls Innate CD8 T Cell Generation.Cell reports · 2019Article
- Differential Control ofFrontiers in immunology · 2019Article
- SOX4 controls invariant NKT cell differentiation by tuning TCR signaling.The Journal of experimental medicine · 2018Article
- IL-17 in neonatal health and disease.American journal of reproductive immunology (New York, N.Y. : 1989) · 2018Review
- Invariant Natural Killer T and Mucosal-Associated Invariant T Cells in Asthmatic Patients.Frontiers in immunology · 2018Review
- Unraveling Natural Killer T-Cells Development.Frontiers in immunology · 2017Review
- Natural Killer T Cells: An Ecological Evolutionary Developmental Biology Perspective.Frontiers in immunology · 2017Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
iNKT cells are a unique lineage of T cells that recognize glycolipid presented by CD1d. In the thymus, they differentiate into iNKT1, iNKT2 and iNKT17 effector subsets, characterized by preferential expression of Tbet, Gata3 and ROR-γt and production of IFN-γ, IL-4 and IL-17, respectively. We demonstrate that the transcriptional regulator Runx1 is essential for the generation of ROR-γt expressing iNKT17 cells. PLZF-cre Runx1 cKO mice lack iNKT17 cells in the thymus, spleen and liver. Runx1-deficient iNKT cells have altered expression of several genes important for iNKT17 differentiation, including decreased expression of IL-7Rα, BATF and c-Maf and increased expression of Bcl11b and Lef1. However, reduction of Lef1 expression or introduction of an IL-7Rα transgene is not sufficient to correct the defect in iNKT17 differentiation, demonstrating that Runx1 is a key regulator of several genes required for iNKT17 differentiation. Loss of Runx1 leads to a severe decrease in iNKT cell numbers in the thymus, spleen and liver. The decrease in cell number is due to a combined decrease in proliferation at Stage 1 during thymic development and increased apoptosis. Thus, we describe a novel role of Runx1 in iNKT cell development and differentiation, particularly in orchestrating iNKT17 differentiation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.