Evidence map›Paper›PMID 28765606›Full record

ArticleScientific reports2017

2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A

Maroula G Kokotou, Gerasimia Galiatsatou, Victoria Magrioti, Giorgos Koutoulogenis, Efrosini Barbayianni, Dimitris Limnios, Varnavas D Mouchlis, Banita Satpathy, Aaron Navratil, Edward A Dennis and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Medicinal chemistry (Shariqah (United Arab Emirates)) · 2024
    Article
  2. Review
  3. Review
  4. 2-Oxoester Phospholipase ABiomolecules · 2020
    Article
  5. Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases ABiochimica et biophysica acta. Molecular and cell biology of lipids · 2019
    Review
  6. Article
  7. Review
  8. Review of four major distinct types of human phospholipase AAdvances in biological regulation · 2018
    Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Maroula G KokotouLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, 15771, Greece.
Gerasimia GaliatsatouLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, 15771, Greece.
Victoria MagriotiLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, 15771, Greece.ORCID 0000-0001-5441-9219
Giorgos KoutoulogenisLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, 15771, Greece.
Efrosini BarbayianniLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, 15771, Greece.
Dimitris LimniosLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, 15771, Greece.
Varnavas D MouchlisDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California, 92093-0601, USA.
Banita SatpathyDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California, 92093-0601, USA.
Aaron NavratilDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California, 92093-0601, USA.
Edward A DennisDepartment of Chemistry and Biochemistry and Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California, 92093-0601, USA. edennis@ucsd.edu.ORCID 0000-0003-3738-3140
George KokotosLaboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis, Athens, 15771, Greece. gkokotos@chem.uoa.gr.ORCID 0000-0003-3753-7082
National and Kapodistrian University of Athens · GRUniversity of California San Diego · US

Funding

ACTION OF LIPOLYTIC ENZYMESR01GM020501 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DENNIS, EDWARD A · 1985 to 2020
$7.3M
DESIGN OF AMPHIPHILIC PEPTOID ASSEMBLIESF32GM020501 · NIGMS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI BURKOTH, TIMOTHY S · 2000 to 2002
$75k
NIGMS NIH HHS F32 GM020501NIGMS NIH HHS R01 GM020501
6 · The paper itself

Abstract

Cytosolic phospholipase A

Indexed as

AnimalsAnti-Inflammatory AgentsEnzyme InhibitorsEstersGroup IV Phospholipases A2Inflammation MediatorsMacrophagesMiceMolecular Docking SimulationRAW 264.7 CellsAnti-Inflammatory AgentsEnzyme InhibitorsEstersGroup IV Phospholipases A2Inflammation Mediators

Identifiers

PMID28765606
PMCPMC5539244
OpenAlexW2738669767

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.