ArticleScientific reports2017
Metabonomics Approach to Assessing the Modulatory Effects of Kisspeptin-10 on Liver Injury Induced by Heat Stress in Rats.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of Extreme Heat Exposure on Heatstroke and Liver Injury in Mice: The Role of PPARα.Environmental health perspectives · 2026Article
- Metabolic and metataxonomic changes in lactating holstein dairy cows during the transition from heat stress to the recovery period.Journal of animal science and technology · 2026Article
- Heat stress mitigation during prepartum and postpartum altered the plasma metabolome in Bos indicus-influenced cow-calf pairs.Journal of animal science · 2025Article
- Kisspeptin a potential therapeutic target in treatment of both metabolic and reproductive dysfunction.Journal of diabetes · 2024Review
- Role of the kisspeptin-KISS1R axis in the pathogenesis of chronic kidney disease and uremic cardiomyopathy.GeroScience · 2024Article
- Acid-Resistant BODIPY Amino Acids for Peptide-Based Fluorescence Imaging of GPR54 Receptors in Pancreatic Islets.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023Article
- Acid-Resistant BODIPY Amino Acids for Peptide-Based Fluorescence Imaging of GPR54 Receptors in Pancreatic Islets.Angewandte Chemie (International ed. in English) · 2023Article
- Higher Concentration of Dietary Selenium, Zinc, and Copper Complex Reduces Heat Stress-Associated Oxidative Stress and Metabolic Alteration in the Blood of Holstein and Jersey Steers.Animals : an open access journal from MDPI · 2022Article
- Identification of Genomic Characteristics and Selective Signals in a Du'an Goat Flock.Animals : an open access journal from MDPI · 2020Article
- Kisspeptin and Metabolism: The Brain and Beyond.Frontiers in endocrinology · 2018Review
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The protective effects of Kisspeptin on heat-induced oxidative stress in rats were investigated by using a combination of biochemical parameters and metabonomics. Metabonomic analyses were performed using gas chromatography/mass spectrometry in conjunction with multivariate and univariate statistical analyses. At the end point of the heat stress experiment, histological observation, ultrastructural analysis and biochemical parameters were measured. Metabonomic analysis of liver tissue revealed that Kisspeptin mainly attenuated the alteration of purine metabolism and fatty acid metabolism pathways. Futhermore, Kisspeptin also increased the levels of GSH, T-AOC as well as SOD activities, and upregulated MDA levels. These results provide important mechanistic insights into the protective effects of Kisspeptin against heat-induced oxidative stress.
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