Evidence map›Paper›PMID 28765286›Full record

ArticleStroke2017

Long-Delay Arterial Spin Labeling Provides More Accurate Cerebral Blood Flow Measurements in Moyamoya Patients: A Simultaneous Positron Emission Tomography/MRI Study.

Audrey P Fan, Jia Guo, Mohammad M Khalighi, Praveen K Gulaka, Bin Shen, Jun Hyung Park, Harsh Gandhi, Dawn Holley, Omar Rutledge, Prachi Singh and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 113 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Elevated brain oxygen extraction fraction measured by MRI susceptibility relates to perfusion status in acute ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020
    Trial
  4. Article
  5. Article
  6. Simultaneous multiple post-labelling delay ASL MRI and [European journal of nuclear medicine and molecular imaging · 2026
    Article
  7. Article
  8. Review
  9. Hyperintense Signals in Cerebral Blood Flow Maps of Mice Acquired with Pseudo-continuous Arterial Spin Labeling MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Audrey P FanFrom the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.). auddie@stanford.edu.
Jia GuoFrom the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.).
Mohammad M KhalighiFrom the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.).
Praveen K GulakaFrom the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.).
Bin ShenFrom the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.).
Jun Hyung ParkFrom the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.).
Harsh GandhiFrom the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.).
Dawn HolleyFrom the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.).
Omar RutledgeFrom the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.).
Prachi SinghFrom the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.).
Tom HaywoodFrom the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.).
Gary K SteinbergFrom the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.).
Frederick T ChinFrom the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.).
Greg ZaharchukFrom the Departments of Radiology (A.P.F., J.G., P.K.G., B.S., J.H.P., H.G., D.H., O.R., P.S., T.H., F.T.C., G.Z.) and Neurosurgery (G.K.S.), Stanford University, CA; and Global Applied Science Lab, GE Healthcare, Menlo Park, CA (M.M.K.).
Applied Sciences Laboratory (United States) · USGeneral Electric (Spain) · ES

Funding

Quantifying Collateral Perfusion in Cerebrovascular DiseaseR01NS066506 · NINDS · STANFORD UNIVERSITY · PI ZAHARCHUK, GREGORY GEORGE · 2009 to 2017
$4.9M
Cerebrovascular Reserve Imaging with Simultaneous PET/MRI Using Arterial Spin Labeling and Deep LearningR01EB025220 · NIBIB · STANFORD UNIVERSITY · PI ZAHARCHUK, GREGORY GEORGE · 2018 to 2021
$2.8M
NIBIB NIH HHS R01 EB025220NINDS NIH HHS R01 NS066506
6 · The paper itself

Abstract

background and purposeArterial spin labeling (ASL) MRI is a promising, noninvasive technique to image cerebral blood flow (CBF) but is difficult to use in cerebrovascular patients with abnormal, long arterial transit times through collateral pathways. To be clinically adopted, ASL must first be optimized and validated against a reference standard in these challenging patient cases.

methodsWe compared standard-delay ASL (post-label delay=2.025 seconds), multidelay ASL (post-label delay=0.7-3.0 seconds), and long-label long-delay ASL acquisitions (post-label delay=4.0 seconds) against simultaneous [

resultsStandard-delay ASL underestimated relative CBF by 20% in areas of severe Tmax delays, particularly in anterior and middle territories commonly affected by Moyamoya disease (

conclusionsPost-label delay times of ≥4 seconds are needed and may be combined with multidelay strategies for robust ASL assessment of CBF in Moyamoya disease.

Indexed as

Cerebrovascular CirculationAdolescentAdultBrainCollateral CirculationFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedMoyamoya DiseaseMultimodal ImagingOxygen RadioisotopesPositron-Emission TomographySpin LabelsOxygen RadioisotopesSpin Labelscerebral blood flowcerebrovascular circulationmagnetic resonance imagingMoyamoya diseasepositron-emission tomography

Identifiers

PMID28765286
PMCPMC8006795
OpenAlexW2741545352

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.