Evidence map›Paper›PMID 28765222›Full record

ArticlemBio2017

Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS-Dependent Virulence Factor Expression in

Megan E Ericson, Chitra Subramanian, Matthew W Frank, Charles O Rock

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Journal of bacteriology · 2025
    Article
  5. Article
  6. Treatment ofAntimicrobial agents and chemotherapy · 2025
    Article
  7. Article
  8. Linking Virulence and Iron Limitation Response inJournal of proteome research · 2025
    Article
  9. Lung surfactant reducesMicrobiology spectrum · 2025
    Article
  10. Review
  11. DisarmingPathogens (Basel, Switzerland) · 2025
    Review
  12. Article
  13. Bacterial acquisition of host fatty acids has far-reaching implications on virulence.Microbiology and molecular biology reviews : MMBR · 2024
    Review
  14. Article
  15. Insights into Kinases of ESKAPE Pathogens for Therapeutic Interventions.Cardiovascular & hematological agents in medicinal chemistry · 2024
    Review
  16. Article
  17. CommensalACS omega · 2023
    Article
  18. Article
  19. Article
  20. Characterization and virulence ofFrontiers in microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Megan E EricsonDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Chitra SubramanianDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Matthew W FrankDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Charles O RockDepartment of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA charles.rock@stjude.org.ORCID 0000-0001-8648-4189
St. Jude Children's Research Hospital · US

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9M
REGULATION OF LIPID METABOLISM IN E COLIR01GM034496 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ROCK, CHARLES O · 1985 to 2022
$9.2M
REGULATION OF LIPID METABOLISM IN BACTERIAR37GM034496 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ROCK, CHARLES O · 2001 to 2010
$5.7M
NCI NIH HHS P30 CA021765NIGMS NIH HHS R01 GM034496NIGMS NIH HHS R37 GM034496
6 · The paper itself

Abstract

The SaeRS two-component system is a master activator of virulence factor transcription in

Indexed as

Bacterial ProteinsFatty AcidsGene Expression Regulation, BacterialHomeostasisMutationPhosphorylationPhosphotransferasesProtein KinasesSignal TransductionStaphylococcus aureusTranscription FactorsVirulence FactorsBacterial ProteinsFatty AcidsPhosphotransferasesProtein KinasesSaeR protein, Staphylococcus aureusSaeS protein, Staphylococcus aureusTranscription FactorsVirulence Factorsfatty acidhemolysinphospholipidStaphylococcus aureustwo-component regulatory systemsvirulence factorsvirulence regulation

Identifiers

PMID28765222
PMCPMC5539427
OpenAlexW2740868806

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.